About: Tumor microenvironment complexity and therapeutic implications at a glance

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Tumor microenvironment complexity and therapeutic implications at a glance
Creator	Jahanban-Esfahlan, Rana Javaheri, Tahereh Jaymand, Mehdi Seidi, Khaled Zare, Peyman »more»
source	PMC
abstract	The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity of cancer cell, clonal evolution and to increase the multidrug resistance ending in cancer cell progression and metastasis. The reciprocal cell-cell/ECM interaction and tumor cell hijacking of non-malignant cells force stromal cells to lose their function and acquire new phenotypes that promote development and invasion of tumor cells. Understanding the underlying cellular and molecular mechanisms governing these interactions can be used as a novel strategy to indirectly disrupt cancer cell interplay and contribute to the development of efficient and safe therapeutic strategies to fight cancer. Furthermore, the tumor-derived circulating materials can also be used as cancer diagnostic tools to precisely predict and monitor the outcome of therapy. This review evaluates such potentials in various advanced cancer models, with a focus on 3D systems as well as lab-on-chip devices.
has issue date	2020-04-07(xsd:dateTime)
bibo:doi	10.1186/s12964-020-0530-4
bibo:pmid	32264958
has license	cc-by
sha1sum (hex)	c53b4adaa6f14f1b5d16fc5026a1a69b03006bf0
schema:url	https://doi.org/10.1186/s12964-020-0530-4
resource representing a document's title	Tumor microenvironment complexity and therapeutic implications at a glance
has PubMed Central identifier	PMC7140346
has PubMed identifier	32264958
schema:publication	Cell Commun Signal
resource representing a document's body	covid:c53b4adaa6f14f1b5d16fc5026a1a69b03006bf0#body_text
is schema:about of	named entity 'materials' named entity 'ECM' named entity 'stromal cells' named entity 'therapy' named entity 'The' »more»

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