About: Broad and potent cross clade neutralizing antibodies with multiple specificities in the plasma of HIV-1 subtype C infected individuals

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About: Broad and potent cross clade neutralizing antibodies with multiple specificities in the plasma of HIV-1 subtype C infected individuals Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Broad and potent cross clade neutralizing antibodies with multiple specificities in the plasma of HIV-1 subtype C infected individuals
Creator	Ashokkumar, Manickam Babu, Hemalatha Buddolla, Viswanath Chandrasekaran, Padmapriyadarsini Cheedarla, Narayanaiah »more»
source	PMC
abstract	Broadly Cross clade Neutralizing (BCN) antibodies are recognized as potential therapeutic tools and leads for the design of a vaccine that can protect human beings against various clades of Human Immunodeficiency Virus (HIV). In the present study, we screened plasma of 88 HIV-1 infected ART naïve individuals for their neutralization potential using a standard panel of 18 pseudoviruses belonging to different subtypes and different levels of neutralization. We identified 12 samples with good breadth of neutralization (neutralized >90% of the viruses). Four of these samples neutralized even the difficult-to-neutralize tier-3 pseudoviruses with great potency (GMT > 600). Analysis of neutralization specificities indicated that four samples had antibodies with multiple epitope binding specificities, viz. CD4-binding site (CD4BS), glycans in the V1/V2 and V3 regions and membrane proximal external region (MPER). Our findings indicate the strong possibility of identifying highly potent bNAbs with known or novel specificities from HIV-1 subtype C infected individuals from India that can be exploited as therapeutic tools or lead molecules for the identification of potential epitopes for design of a protective HIV-1 vaccine.
has issue date	2017-04-24(xsd:dateTime)
bibo:doi	10.1038/srep46557
bibo:pmid	28436427
has license	cc-by
sha1sum (hex)	c5139e673b41fa64eb80936bc9d63e83bf3c7172
schema:url	https://doi.org/10.1038/srep46557
resource representing a document's title	Broad and potent cross clade neutralizing antibodies with multiple specificities in the plasma of HIV-1 subtype C infected individuals
has PubMed Central identifier	PMC5402285
has PubMed identifier	28436427
schema:publication	Sci Rep
resource representing a document's body	covid:c5139e673b41fa64eb80936bc9d63e83bf3c7172#body_text
is schema:about of	covid:arg/c5139e673b41fa64eb80936bc9d63e83bf3c7172 named entity 'IgG' named entity 'HIV-2' named entity 'incubation' named entity 'V3 loop' »more»

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