About: Unveiling diffusion pattern and structural impact of the most invasive SARS-CoV-2 spike mutation

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About: Unveiling diffusion pattern and structural impact of the most invasive SARS-CoV-2 spike mutation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Unveiling diffusion pattern and structural impact of the most invasive SARS-CoV-2 spike mutation
Creator	Bertorelle, Giorgio Cicconardi, Francesco D'annessa, Ilda Gratton, Paolo Mafessoni, Fabrizio »more»
source	BioRxiv
abstract	Starting in Wuhan, China, SARS-CoV-2 epidemics quickly propagated worldwide in less than three months, geographically sorting genomic variants in newly established propagules of infections. Stochasticity in transmission within and between countries and/or actual advantage in virus transmissibility could explain the high frequency reached by some genomic variants during the course of the outbreak. Using a suite of statistical, population genetics, and theoretical approaches, we show that the globally most represented spike protein variant (i.e., the G clade, A → G nucleotide change at genomic position 23,403; D → G amino acid change at spike protein position 614) i) underwent a significant demographic expansion in most countries not explained by stochastic effects or enhanced pathogenicity; ii) affects the spike S1/S2 furin-like site increasing its conformational plasticity (short range effect), and iii) modifies the internal motion of the receptor-binding domain affecting its cross-connection with other functional domains (long-range effect). Our study unambiguously links the spread of the G614 with a non-random process, and we hypothesize that this process is related to the selective advantage produced by a specific structural modification of the spike protein. We conclude that the different conformation of the S1/S2 proteolytic site is at the basis of the higher transmission rate of this invasive SARS-CoV-2 variant, and provide structural information to guide the design of selective and efficient drugs.
has issue date	2020-05-15(xsd:dateTime)
bibo:doi	10.1101/2020.05.14.095620
has license	biorxiv
sha1sum (hex)	c3f3a845e9cd3c054778069e2eb8c5486a16d1a2
schema:url	https://doi.org/10.1101/2020.05.14.095620
resource representing a document's title	Unveiling diffusion pattern and structural impact of the most invasive SARS-CoV-2 spike mutation
schema:publication	bioRxiv
resource representing a document's body	covid:c3f3a845e9cd3c054778069e2eb8c5486a16d1a2#body_text
is schema:about of	named entity 'virus' named entity 'GENOMIC' named entity 'OUTBREAK' named entity 'high frequency' named entity 'Wuhan' »more»

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