About: Porcine deltacoronavirus activates the Raf/MEK/ERK pathway to promote its replication

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About: Porcine deltacoronavirus activates the Raf/MEK/ERK pathway to promote its replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Porcine deltacoronavirus activates the Raf/MEK/ERK pathway to promote its replication
Creator	Lee, Changhee Jeon, Ji Lee, Yoo
source	Elsevier; Medline; PMC
abstract	Abstract Porcine deltacoronavirus (PDCoV) is a newly emerged swine coronavirus that causes acute enteritis in neonatal piglets. To date, little is known about the host factors or cellular signaling mechanisms associated with PDCoV replication. Since the Raf/MEK/ERK pathway is involved in modulation of various important cellular functions, numerous DNA and RNA viruses coopt this pathway for efficient propagation. In the present study, we found that PDCoV induces the activation of ERK1/2 and its downstream substrate Elk-1 early in infection irrespective of viral biosynthesis. Chemical inhibition or knockdown of ERK1/2 significantly suppressed viral replication, whereas treatment with an ERK activator increased viral yields. Direct pharmacological inhibition of ERK activation had no effect on the viral entry process but sequentially affected the post-entry steps of the virus life cycle. In addition, pharmacological sequestration of cellular or viral cholesterol downregulated PDCoV-induced ERK signaling, highlighting the significance of the cholesterol contents in ERK activation. However, ERK inhibition had no effect on PDCoV-triggered apoptosis through activation of the cytochrome c-mediated intrinsic mitochondrial pathway, suggesting the irrelevance of ERK activation to the apoptosis pathway during PDCoV infection. Altogether, our findings indicate that the ERK signaling pathway plays a pivotal role in viral biosynthesis to facilitate the optimal replication of PDCoV.
has issue date	2020-07-02(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2020.197961
bibo:pmid	32283129
has license	els-covid
sha1sum (hex)	c3eb9aa04ddf6a74a7c4bebb18729b62c0be81d2
schema:url	https://doi.org/10.1016/j.virusres.2020.197961
resource representing a document's title	Porcine deltacoronavirus activates the Raf/MEK/ERK pathway to promote its replication
has PubMed Central identifier	PMC7194644
has PubMed identifier	32283129
schema:publication	Virus Research
resource representing a document's body	covid:c3eb9aa04ddf6a74a7c4bebb18729b62c0be81d2#body_text
is schema:about of	named entity 'cholesterol' named entity 'steps' named entity 'mitochondrial' named entity 'highlighting' named entity 'deltacoronavirus' »more»

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