About: Artificial microRNAs can effectively inhibit replication of Venezuelan equine encephalitis virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Artificial microRNAs can effectively inhibit replication of Venezuelan equine encephalitis virus
Creator	Bhomia, Manish Gayen, Manoshi Gupta, Paridhi Sharma, Anuj Maheshwari, Radha
source	Elsevier; Medline; PMC
abstract	Abstract Venezuelan equine encephalitis virus is a member of the alphavirus family and genus togaviridae. VEEV is highly infectious in aerosol form and has been weaponized in the past making it a potential biothreat agent. At present, there are no FDA approved antiviral treatments or vaccines for VEEV. Artificial microRNAs are small molecules which are expressed through endogenous microRNA machinery by RNA polymerase II. These artificial microRNAs effectively inhibit gene expression and are non-toxic to the host cell. VEEV RNA dependent RNA polymerase (RdRp) is central to VEEV replication. Therefore, we hypothesize that targeted inhibition of VEEV RdRp using artificial microRNAs may efficiently inhibit VEEV replication. Five artificial microRNAs were tested in vitro in BHK cells. Three of these artificial miRNAs showed significant inhibition of VEEV replication. Further, these microRNAs were cloned into the expression vector in combination to see the synergistic effect on VEEV replication. Combination of more than one miRNA did not result in significant inhibition of virus replication. In conclusion, we have shown that RNAi through artificial microRNAs effectively inhibits VEEV replication and is significantly less toxic in comparison to siRNAs.
has issue date	2013-11-30(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2013.08.010
bibo:pmid	23988697
has license	els-covid
sha1sum (hex)	c3ac316e4528ab9a0050e0b755d47bdc997f488d
schema:url	https://doi.org/10.1016/j.antiviral.2013.08.010
resource representing a document's title	Artificial microRNAs can effectively inhibit replication of Venezuelan equine encephalitis virus
has PubMed Central identifier	PMC7113778
has PubMed identifier	23988697
schema:publication	Antiviral Research
resource representing a document's body	covid:c3ac316e4528ab9a0050e0b755d47bdc997f488d#body_text
is schema:about of	named entity 'ARTIFICIAL' named entity 'gene' named entity 'Venezuelan equine encephalitis virus' named entity 'TESTED' named entity 'THESE' »more»

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