About: Worldwide tracing of mutations and the evolutionary dynamics of SARS-CoV-2

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About: Worldwide tracing of mutations and the evolutionary dynamics of SARS-CoV-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Worldwide tracing of mutations and the evolutionary dynamics of SARS-CoV-2
Creator	Liu, Di Lu, Jian Li, Aimin Li, Haipeng Zhang, Ya-Ping »more»
source	BioRxiv
abstract	Understanding the mutational and evolutionary dynamics of SARS-CoV-2 is essential for treating COVID-19 and the development of a vaccine. Here, we analyzed publicly available 15,818 assembled SARS-CoV-2 genome sequences, along with 2,350 raw sequence datasets sampled worldwide. We investigated the distribution of inter-host single nucleotide polymorphisms (inter-host SNPs) and intra-host single nucleotide variations (iSNVs). Mutations have been observed at 35.6% (10,649/29,903) of the bases in the genome. The substitution rate in some protein coding regions is higher than the average in SARS-CoV-2 viruses, and the high substitution rate in some regions might be driven to escape immune recognition by diversifying selection. Both recurrent mutations and human-to-human transmission are mechanisms that generate fitness advantageous mutations. Furthermore, the frequency of three mutations (S protein, F400L; ORF3a protein, T164I; and ORF1a protein, Q6383H) has gradual increased over time on lineages, which provides new clues for the early detection of fitness advantageous mutations. Our study provides theoretical support for vaccine development and the optimization of treatment for COVID-19. We call researchers to submit raw sequence data to public databases.
has issue date	2020-08-10(xsd:dateTime)
bibo:doi	10.1101/2020.08.07.242263
has license	biorxiv
sha1sum (hex)	c2b3c31392e800a22960d10f3d74421b498d8f8f
schema:url	https://doi.org/10.1101/2020.08.07.242263
resource representing a document's title	Worldwide tracing of mutations and the evolutionary dynamics of SARS-CoV-2
schema:publication	bioRxiv
resource representing a document's body	covid:c2b3c31392e800a22960d10f3d74421b498d8f8f#body_text
is schema:about of	named entity 'viruses' named entity 'vaccine' named entity 'databases' named entity 'Our' named entity 'China' »more»

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