About: Cluster randomised controlled trial to examine medical mask use as source control for people with respiratory illness

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About: Cluster randomised controlled trial to examine medical mask use as source control for people with respiratory illness Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cluster randomised controlled trial to examine medical mask use as source control for people with respiratory illness
Creator	Zhang, Yi Seale, Holly Chu, Yanhui Wang, Quanyi Zhang, Haiyan »more»
source	Medline; PMC
abstract	RATIONALE: Medical masks are commonly used by sick individuals with influenza-like illness (ILI) to prevent spread of infections to others, but clinical efficacy data are absent. OBJECTIVE: Determine whether medical mask use by sick individuals with ILI protects well contacts from related respiratory infections. SETTING: 6 major hospitals in 2 districts of Beijing, China. DESIGN: Cluster randomised controlled trial. PARTICIPANTS: 245 index cases with ILI. INTERVENTION: Index cases with ILI were randomly allocated to medical mask (n=123) and control arms (n=122). Since 43 index cases in the control arm also used a mask during the study period, an as-treated post hoc analysis was performed by comparing outcomes among household members of index cases who used a mask (mask group) with household members of index cases who did not use a mask (no-mask group). MAIN OUTCOME MEASURE: Primary outcomes measured in household members were clinical respiratory illness, ILI and laboratory-confirmed viral respiratory infection. RESULTS: In an intention-to-treat analysis, rates of clinical respiratory illness (relative risk (RR) 0.61, 95% CI 0.18 to 2.13), ILI (RR 0.32, 95% CI 0.03 to 3.13) and laboratory-confirmed viral infections (RR 0.97, 95% CI 0.06 to 15.54) were consistently lower in the mask arm compared with control, although not statistically significant. A post hoc comparison between the mask versus no-mask groups showed a protective effect against clinical respiratory illness, but not against ILI and laboratory-confirmed viral respiratory infections. CONCLUSIONS: The study indicates a potential benefit of medical masks for source control, but is limited by small sample size and low secondary attack rates. Larger trials are needed to confirm efficacy of medical masks as source control. TRIAL REGISTRATION NUMBER: ACTRN12613000852752; Results.
has issue date	2016-12-30(xsd:dateTime)
bibo:doi	10.1136/bmjopen-2016-012330
bibo:pmid	28039289
has license	cc-by
sha1sum (hex)	c14ce2c27ca770924c1ca4a4fef0fa5b532f73c1
schema:url	https://doi.org/10.1136/bmjopen-2016-012330
resource representing a document's title	Cluster randomised controlled trial to examine medical mask use as source control for people with respiratory illness
has PubMed Central identifier	PMC5223715
has PubMed identifier	28039289
schema:publication	BMJ Open
resource representing a document's body	covid:c14ce2c27ca770924c1ca4a4fef0fa5b532f73c1#body_text
is schema:about of	named entity 'mask' named entity 'source control' named entity 'PEOPLE' named entity 'USE' named entity 'RESPIRATORY ILLNESS' »more»

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