About: Bacterial Complications of Respiratory Tract Viral Illness: A Comprehensive Evaluation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Bacterial Complications of Respiratory Tract Viral Illness: A Comprehensive Evaluation
Creator	Baran, Andrea Falsey, Ann Walsh, Edward Formica, Maria Becker, Kenneth »more»
source	Medline; PMC
abstract	Background. Respiratory tract infection is one of the most common reasons for hospitalization among adults, and recent evidence suggests that many of these illnesses are associated with viruses. Although bacterial infection is known to complicate viral infections, the frequency and impact of mixed viral-bacterial infections has not been well studied. Methods. Adults hospitalized with respiratory illness during 3 winters underwent comprehensive viral and bacterial testing. This assessment was augmented by measuring the serum level of procalcitonin (PCT) as a marker of bacterial infection. Mixed viral-bacterial infection was defined as a positive viral test result plus a positive bacterial assay result or a serum PCT level of ≥ 0.25 ng/mL on admission or day 2 of hospitalization. Results. Of 842 hospitalizations (771 patients) evaluated, 348 (41%) had evidence of viral infection. A total of 212 hospitalizations (61%) involved patients with viral infection alone. Of the remaining 136 hospitalizations (39%) involving viral infection, results of bacterial tests were positive in 64 (18%), and PCT analysis identified bacterial infection in an additional 72 (21%). Subjects hospitalized with mixed viral-bacterial infections were older and more commonly received a diagnosis of pneumonia. Over 90% of hospitalizations in both groups involved subjects who received antibiotics. Notably, 4 of 10 deaths among subjects hospitalized with viral infection alone were secondary to complications of Clostridium difficile colitis. Conclusions. Bacterial coinfection is associated with approximately 40% of viral respiratory tract infections requiring hospitalization. Patients with positive results of viral tests should be carefully evaluated for concomitant bacterial infection. Early empirical antibiotic therapy for patients with an unstable condition is appropriate but is not without risk.
has issue date	2013-05-09(xsd:dateTime)
bibo:doi	10.1093/infdis/jit190
bibo:pmid	23661797
has license	bronze-oa
sha1sum (hex)	c10ed03edfb97eb2fff8b5e28f43c0c97d9a305c
schema:url	https://doi.org/10.1093/infdis/jit190
resource representing a document's title	Bacterial Complications of Respiratory Tract Viral Illness: A Comprehensive Evaluation
has PubMed Central identifier	PMC3699009
has PubMed identifier	23661797
schema:publication	Journal of Infectious Diseases
resource representing a document's body	covid:c10ed03edfb97eb2fff8b5e28f43c0c97d9a305c#body_text
is schema:about of	named entity 'common' named entity 'ILLNESSES' named entity 'RECENT' named entity 'EVIDENCE' named entity 'THESE' »more»

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