About: Full genome viral sequences inform patterns of SARS-CoV-2 spread into and within Israel

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About: Full genome viral sequences inform patterns of SARS-CoV-2 spread into and within Israel Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Full genome viral sequences inform patterns of SARS-CoV-2 spread into and within Israel
Creator	Koelle, Katia Shemer-Avni, Yonat Martin, Michael Kustin, Talia Stern, Adi »more»
source	MedRxiv
abstract	Full genome sequences are increasingly used to track the geographic spread and transmission dynamics of viral pathogens. Here, with a focus on Israel, we sequenced 212 SARS-CoV-2 sequences and use them to perform a comprehensive analysis to trace the origins and spread of the virus. A phylogenetic analysis including thousands of globally sampled sequences allowed us to infer multiple independent introductions into Israel, followed by local transmission. Returning travelers from the U.S. contributed dramatically more to viral spread relative to their proportion in incoming infected travelers. Using phylodynamic analysis, we estimated that the basic reproduction number of the virus was initially around ~2.0-2.6, dropping by two-thirds following the implementation of social distancing measures. A comparison between reported and model-estimated case numbers indicated high levels of transmission heterogeneity in SARS-CoV-2 spread, with between 1-10% of infected individuals resulting in 80% of secondary infections. Overall, our findings underscore the ability of this virus to efficiently transmit between and within countries, as well as demonstrate the effectiveness of social distancing measures for reducing its spread.
has issue date	2020-05-22(xsd:dateTime)
bibo:doi	10.1101/2020.05.21.20104521
has license	medrxiv
sha1sum (hex)	bf278aa85d4191ae92b05c3f7590313d658fef4c
schema:url	https://doi.org/10.1101/2020.05.21.20104521
resource representing a document's title	Full genome viral sequences inform patterns of SARS-CoV-2 spread into and within Israel
resource representing a document's body	covid:bf278aa85d4191ae92b05c3f7590313d658fef4c#body_text
is schema:about of	named entity 'ability' named entity 'underscore' named entity 'patterns' named entity 'viral' named entity 'TRACE' »more»

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