About: Identification of Plakortide E from the Caribbean Sponge Plakortis halichondroides as a Trypanocidal Protease Inhibitor using Bioactivity-Guided Fractionation

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About: Identification of Plakortide E from the Caribbean Sponge Plakortis halichondroides as a Trypanocidal Protease Inhibitor using Bioactivity-Guided Fractionation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification of Plakortide E from the Caribbean Sponge Plakortis halichondroides as a Trypanocidal Protease Inhibitor using Bioactivity-Guided Fractionation
Creator	Hentschel, Ute Oli, Swarna Schirmeister, Tanja Ramadan Abdelmohsen, Usama
source	Medline; PMC
abstract	In this paper, we report new protease inhibitory activity of plakortide E towards cathepsins and cathepsin-like parasitic proteases. We further report on its anti-parasitic activity against Trypanosoma brucei with an IC(50) value of 5 μM and without cytotoxic effects against J774.1 macrophages at 100 μM concentration. Plakortide E was isolated from the sponge Plakortis halichondroides using enzyme assay-guided fractionation and identified by NMR spectroscopy and mass spectrometry. Furthermore, enzyme kinetic studies confirmed plakortide E as a non-competitive, slowly-binding, reversible inhibitor of rhodesain.
has issue date	2014-05-02(xsd:dateTime)
bibo:doi	10.3390/md12052614
bibo:pmid	24798927
has license	cc-by
sha1sum (hex)	bdd49a68f33046aa3a724721b7050c5f548f90de
schema:url	https://doi.org/10.3390/md12052614
resource representing a document's title	Identification of Plakortide E from the Caribbean Sponge Plakortis halichondroides as a Trypanocidal Protease Inhibitor using Bioactivity-Guided Fractionation
has PubMed Central identifier	PMC4052307
has PubMed identifier	24798927
schema:publication	Mar Drugs
resource representing a document's body	covid:bdd49a68f33046aa3a724721b7050c5f548f90de#body_text
is schema:about of	named entity 'parasitic' named entity 'Protease' named entity 'SPONGE' named entity 'PLAKORTIDE E' named entity 'USING' »more»

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