About: The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent
Creator	Biron, Christine Dunn, Matthew Gardner, Christina Hartman, Amy Klimstra, William »more»
source	PMC
abstract	Interferon alpha/beta (IFN-α/β) is a critical mediator of protection against most viruses, with host survival frequently impossible in its absence. Many studies have investigated the pathways involved in the induction of IFN-α/β after virus infection and the resultant upregulation of antiviral IFN-stimulated genes (ISGs) through IFN-α/β receptor complex signaling. However, other than examining the effects of genetic deletion of induction or effector pathway components, little is known regarding the functionality of these responses in intact hosts and whether host genetic or environmental factors might influence their potency. Here, we demonstrate that the IFN-α/β response against multiple arthropod-vectored viruses, which replicate over a wide temperature range, is extremely sensitive to fluctuations in temperature, exhibiting reduced antiviral efficacy at subnormal cellular temperatures and increased efficacy at supranormal temperatures. The effect involves both IFN-α/β and ISG upregulation pathways with a major aspect of altered potency reflecting highly temperature-dependent transcription of IFN response genes that leads to altered IFN-α/β and ISG protein levels. Discordantly, signaling steps prior to transcription that were examined showed the opposite effect from gene transcription, with potentiation at low temperature and inhibition at high temperature. Finally, we demonstrate that by lowering the temperature of mice, chikungunya arbovirus replication and disease are exacerbated in an IFN-α/β-dependent manner. This finding raises the potential for use of hyperthermia as a therapeutic modality for viral infections and in other contexts such as antitumor therapy. The increased IFN-α/β efficacy at high temperatures may also reflect an innate immune-relevant aspect of the febrile response.
has issue date	2018-04-24(xsd:dateTime)
bibo:doi	10.1128/mbio.00535-18
bibo:pmid	29691338
has license	cc-by
sha1sum (hex)	bd96aabb0e4aa01c5310bf23827eb32168779a7c
schema:url	https://doi.org/10.1128/mbio.00535-18
resource representing a document's title	The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent
has PubMed Central identifier	PMC5915735
has PubMed identifier	29691338
schema:publication	mBio
resource representing a document's body	covid:bd96aabb0e4aa01c5310bf23827eb32168779a7c#body_text
is schema:about of	named entity 'hosts' named entity 'viral infections' named entity 'replicate' named entity 'chikungunya' named entity 'involved' »more»

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