About: First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease

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About: First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease
Creator	Daniel, · Fernando, · Carlos, · Claro, Ingra Domingues, Renan »more»
source	Medline; PMC
abstract	The association between coronaviruses and central nervous system (CNS) demyelinating lesions has been previously shown. However, no case has been described of an association between the novel coronavirus (SARS-COV-2) and CNS demyelinating disease so far. SARS-COV-2 was previously detected in cerebrospinal fluid (CSF) sample of a patient with encephalitis. However, the virus identity was not confirmed by deep sequencing of SARS-COV-2 detected in the CSF. Here, we report a case of a patient with mild respiratory symptoms and neurological manifestations compatible with clinically isolated syndrome. The viral genome of SARS-COV-2 was detected and sequenced in CSF with 99.74–100% similarity between the patient virus and worldwide sequences. This report suggests a possible association of SARS-COV-2 infection with neurological symptoms of demyelinating disease, even in the absence of relevant upper respiratory tract infection signs.
has issue date	2020-06-20(xsd:dateTime)
bibo:doi	10.1007/s00415-020-09996-w
bibo:pmid	32564153
has license	no-cc
sha1sum (hex)	bcd25643744df569cf4e8d5c65ec897a77e18fe3
schema:url	https://doi.org/10.1007/s00415-020-09996-w
resource representing a document's title	First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease
has PubMed Central identifier	PMC7305694
has PubMed identifier	32564153
schema:publication	J Neurol
resource representing a document's body	covid:bcd25643744df569cf4e8d5c65ec897a77e18fe3#body_text
is schema:about of	named entity 'symptoms' named entity 'coronaviruses' named entity 'upper respiratory tract infection' named entity 'virus' named entity 'coronavirus' »more»

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