About: The First Transmembrane Domain of Lipid Phosphatase SAC1 Promotes Golgi Localization

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The First Transmembrane Domain of Lipid Phosphatase SAC1 Promotes Golgi Localization
Creator	Chen, J Enns, C Mayinger, P Wang, J
source	Medline; PMC
abstract	The lipid phosphatase Sac1 cycles between endoplasmic reticulum and cisternal Golgi compartments. In proliferating mammalian cells, a canonical dilysine motif at the C-terminus of Sac1 is required for coatomer complex-I (COP-I)-binding and continuous retrieval to the ER. Starvation triggers accumulation of Sac1 at the Golgi. The mechanism responsible for Golgi retention of Sac1 is unknown. Here we show that the first of the two transmembrane regions in human SAC1 (TM1) functions in Golgi localization. A minimal construct containing only TM1 and the adjacent flanking sequences is concentrated at the Golgi. Transplanting TM1 into transferrin receptor 2 (TfR2) induces Golgi accumulation of this normally plasma membrane and endosomal protein, indicating that TM1 is sufficient for Golgi localization. In addition, we determined that the N-terminal cytoplasmic domain of SAC1 also promotes Golgi localization, even when TM1 is mutated or absent. We conclude that the distribution of SAC1 within the Golgi is controlled via both passive membrane thickness-dependent partitioning of TM1 and a retention mechanism that requires the N-terminal cytoplasmic region.
has issue date	2013-08-01(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0071112
bibo:pmid	23936490
has license	cc-by
sha1sum (hex)	baa8420ed8f9d0dc7ba81b519eda2c3fe91291b8
schema:url	https://doi.org/10.1371/journal.pone.0071112
resource representing a document's title	The First Transmembrane Domain of Lipid Phosphatase SAC1 Promotes Golgi Localization
has PubMed Central identifier	PMC3731292
has PubMed identifier	23936490
schema:publication	PLoS One
resource representing a document's body	covid:baa8420ed8f9d0dc7ba81b519eda2c3fe91291b8#body_text
is schema:about of	named entity 'endosomal' named entity 'transmembrane regions' named entity 'localization' named entity 'lipid' named entity 'proliferating' »more»

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