About: SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors

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About: SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors
Creator	Ivanov, Alexander Efimov, Grigory Titov, Aleksei Shugay, Mikhail Bagaev, Dmitry »more»
source	MedRxiv
abstract	Understanding the determinants of adaptive immune response to SARS-CoV-2 is critical for fighting the ongoing COVID-19 pandemic. Here we assayed both antibody and T-cell reactivity to SARS-CoV-2 antigens in COVID-19 convalescent patients and healthy donors sampled before and during the pandemic. Our results show that while anti-SARS-CoV-2 antibodies can distinguish convalescent patients from healthy donors, the magnitude of T-cell response was more pronounced in healthy donors sampled during COVID-19 pandemic than in donors sampled before the outbreak. This hints at the possibility that some individuals have encountered the virus but were protected by T-cell cross-reactivity observed. A public and diverse T-cell response was observed for two A*02-restricted SARS-CoV-2 epitopes, revealing a set of T-cell receptor motifs displaying germline-encoded features. Bulk CD4+ and CD8+ T-cell response to SARS-CoV-2 glycoprotein S is characterized by multiple groups of homologous T-cell receptor sequences some of which are shared across multiple donors, indicating the existence of immunodominant epitopes. Overall, our findings indicate that T cells form an efficient response to SARS-CoV-2 and alongside the antibodies can serve as a useful biomarker for surveying SARS-CoV-2 exposure and immunity. We hope that data, including the set of specific T-cell receptors identified in this study can serve as a basis for future developments of SARS-CoV-2 vaccinations and monitoring.
has issue date	2020-05-25(xsd:dateTime)
bibo:doi	10.1101/2020.05.20.20107813
has license	medrxiv
sha1sum (hex)	b8b5da1bfaf2299e0e8b5008fd13a607bf2638b4
schema:url	https://doi.org/10.1101/2020.05.20.20107813
resource representing a document's title	SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors
resource representing a document's body	covid:b8b5da1bfaf2299e0e8b5008fd13a607bf2638b4#body_text
is schema:about of	named entity 'antibody' named entity 'donors' named entity 'identified' named entity 'biomarker' named entity 'pandemic' »more»

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