About: The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage

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About: The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage
Creator	Peiris, Malik Zhu, Huachen Yang, Zi Hok, Horace Lee, Yeung »more»
source	PMC
abstract	A novel avian-origin influenza A (H7N9) virus emerged in China in 2013 and has caused zoonotic disease in over 1123 persons with an overall mortality around 30%. Amino acid changes at the residues 591, 627 and 701 of polymerase basic protein 2 (PB2) have been found frequently in the human H7N9 isolates but not in viruses isolated from avian species. We have recently identified a cluster of H7N9 viruses in ducks which circulated in China prior to the first recognition of zoonotic disease in 2013. These duck viruses have genetic background distinct from the zoonotic H7N9 lineage. We found that the introduction of PB2 mutation with K at 627 but not K at 591 or N at 701 to the duck H7N9 virus led to increased pathogenicity in mice. We also found that the induction of pro-inflammatory cytokines including TNF-α, IP-10, MCP-1 and MIP-1α were associated with increased severity of infection. We conclude that introduction of the mammalian adaptation mutations into the PB2 gene of duck H7N9 viruses, which are genetically unrelated to the zoonotic H7N9 lineage, can also enhance pathogenicity in mice.
has issue date	2017-05-24(xsd:dateTime)
bibo:doi	10.1038/s41598-017-02598-z
bibo:pmid	28539661
has license	cc-by
sha1sum (hex)	b83f9595c9669da923281321541bba417ae5f848
schema:url	https://doi.org/10.1038/s41598-017-02598-z
resource representing a document's title	The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage
has PubMed Central identifier	PMC5443809
has PubMed identifier	28539661
schema:publication	Sci Rep
resource representing a document's body	covid:b83f9595c9669da923281321541bba417ae5f848#body_text
is schema:about of	named entity 'virus' named entity 'H7N9' named entity 'PCR amplification' named entity 'plasmid' named entity 'biosafety level 3' »more»

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