About: Multidomain Interventions to Prevent Cognitive Impairment, Alzheimer’s Disease, and Dementia: From FINGER to World-Wide FINGERS

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Multidomain Interventions to Prevent Cognitive Impairment, Alzheimer’s Disease, and Dementia: From FINGER to World-Wide FINGERS
Creator	Kivipelto, M Mangialasche, F Ngandu, T Rosenberg, A Solomon, A
source	PMC
abstract	Alzheimer’s disease (AD) and dementia are a global public health priority, and prevention has been highlighted as a pivotal component in managing the dementia epidemic. Modifiable risk factors of dementia and AD include lifestyle-related factors, vascular and metabolic disorders, and psychosocial factors. Randomized controlled clinical trials (RCTs) are needed to clarify whether modifying such factors can prevent or postpone cognitive impairment and dementia in older adults. Given the complex, multifactorial, and heterogeneous nature of late-onset AD and dementia, interventions targeting several risk factors and mechanisms simultaneously may be required for optimal preventive effects. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is the first large, long-term RCT to demonstrate that a multidomain lifestyle-based intervention ameliorating vascular and lifestyle-related risk factors can preserve cognitive functioning and reduce the risk of cognitive decline among older adults at increased risk of dementia. To investigate the multidomain intervention in other populations and diverse cultural and geographical settings, the World-Wide FINGERS (WW-FINGERS) network was recently launched (https://alz.org/wwfingers). Within this network, new FINGER-type trials with shared core methodology, but local culture and context-specific adaptations, will be conducted in several countries. The WW-FINGERS initiative facilitates international collaborations, provides a platform for testing multidomain strategies to prevent cognitive impairment and dementia, and aims at generating high-quality scientific evidence to support public health and clinical decision-making. Furthermore, the WW-FINGERS network can support the implementation of preventive strategies and translation of research findings into practice.
has issue date	2019-10-10(xsd:dateTime)
bibo:doi	10.14283/jpad.2019.41
bibo:pmid	32010923
has license	cc-by
sha1sum (hex)	b6fbfcb507d5a5002b7660ea787e0d5ef696abee
schema:url	https://doi.org/10.14283/jpad.2019.41
resource representing a document's title	Multidomain Interventions to Prevent Cognitive Impairment, Alzheimer’s Disease, and Dementia: From FINGER to World-Wide FINGERS
has PubMed Central identifier	PMC7222931
has PubMed identifier	32010923
schema:publication	J Prev Alzheimers Dis
resource representing a document's body	covid:b6fbfcb507d5a5002b7660ea787e0d5ef696abee#body_text
is schema:about of	named entity 'complex' named entity 'cognitive impairment' named entity 'older adults' named entity 'heterogeneous' named entity 'dementia' »more»

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