About: Genotypic diversity, circulation patterns, and co-detections among rhinoviruses in Queensland, 2001

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About: Genotypic diversity, circulation patterns, and co-detections among rhinoviruses in Queensland, 2001 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genotypic diversity, circulation patterns, and co-detections among rhinoviruses in Queensland, 2001
Creator	Arden, Katherine Mackay, Ian Greer Phd, Ristan Wang, Claire
source	BioRxiv; MedRxiv
abstract	Rhinoviruses (RVs) occur more frequently than other viruses and more often in people displaying symptoms than in those without. RVs exacerbate chronic airway disease and confound the clinical diagnosis of influenza-like illness. We sought to estimate the spectrum of RV diversity, RV species seasonality and to breakdown RV involvement in respiratory virus co-detections by comprehensive molecular testing of a convenience collection of airway sample extracts from patients with suspected respiratory infections, collected during 2001. RVs were the most common virus detected. We were able to genotype ∼90% of RV detections, identifying 70 distinct RVs, spanning all three species. RV-Bs were under-represented. We found RV species co-circulated at times, although one species usually dominated. Each species displayed a bimodal distribution. Notably, RVs and influenza A viruses (IFAV) seldom co-occurred, supporting their roles as primary pathogens of the airway among acutely ill infants. Whether RV circulation has a moderating or controlling effect on the IFAV season or is controlled by it cannot be determined from these data. Despite the frequent perception that RVs commonly co-occur with another virus, our findings indicated this was not the case. Nearly 80% of RV detections occurred alone. Understanding more about population-level interference between viruses may allow us to harness aspects of it to generate a non-specific antiviral intervention that mimics a putative protective effect. For routine respiratory virus screening to best serve the patient, RV testing should be a principal component of any acute respiratory illness testing algorithm throughout the year.
has issue date	2018-05-30(xsd:dateTime)
bibo:doi	10.1101/334334
has license	biorxiv
sha1sum (hex)	b6bde9469ea1739569ed08a04fd345f295ddece6
schema:url	https://doi.org/10.1101/334334
resource representing a document's title	Genotypic diversity, circulation patterns, and co-detections among rhinoviruses in Queensland, 2001
schema:publication	bioRxiv
resource representing a document's body	covid:b6bde9469ea1739569ed08a04fd345f295ddece6#body_text
is schema:about of	named entity 'seasonality' named entity 'confound' named entity 'respiratory infections' named entity 'BREAKDOWN' named entity 'SAMPLE' »more»

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