About: Nucleotide-binding oligomerization domain-like receptor X1 restricts porcine reproductive and respiratory syndrome virus-2 replication by interacting with viral Nsp9

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About: Nucleotide-binding oligomerization domain-like receptor X1 restricts porcine reproductive and respiratory syndrome virus-2 replication by interacting with viral Nsp9 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Nucleotide-binding oligomerization domain-like receptor X1 restricts porcine reproductive and respiratory syndrome virus-2 replication by interacting with viral Nsp9
Creator	Zhang, Yan Ding, Zhen Jing, Huiyuan Wang, Ting Bao, Wenqi »more»
source	Elsevier; Medline; PMC
abstract	Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) causes one of the most economically important diseases of swine worldwide. Current antiviral strategies provide only limited protection. Nucleotide-binding oligomerization domain-like receptor (NLR) X1 is unique among NLR proteins in its functions as a pro-viral or antiviral factor to different viral infections. To date, the impact of NLRX1 on PRRSV infection remains unclear. In this study, we found that PRRSV infection promoted the expression of NLRX1 gene. In turn, ectopic expression of NLRX1 inhibited PRRSV replication in Marc-145 cells, whereas knockdown of NLRX1 enhanced PRRSV propagation in porcine alveolar macrophages (PAMs). Mechanistically, NLRX1 was revealed to impair intracellular viral subgenomic RNAs accumulation. Finally, Mutagenic analyses indicated that the LRR (leucine-rich repeats) domain of NLRX1 interacted with PRRSV Nonstructural Protein 9 (Nsp9) RdRp (RNA-dependent RNA Polymerase) domain and was necessary for antiviral activity. Thus, our study establishes the role of NLRX1 as a new host restriction factor in PRRSV infection.
has issue date	2019-07-15(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2019.05.011
bibo:pmid	31132368
has license	els-covid
sha1sum (hex)	b5a78b61d406871703b3fd4173f1fd6c8b8f31e8
schema:url	https://doi.org/10.1016/j.virusres.2019.05.011
resource representing a document's title	Nucleotide-binding oligomerization domain-like receptor X1 restricts porcine reproductive and respiratory syndrome virus-2 replication by interacting with viral Nsp9
has PubMed Central identifier	PMC7114581
has PubMed identifier	31132368
schema:publication	Virus Research
resource representing a document's body	covid:b5a78b61d406871703b3fd4173f1fd6c8b8f31e8#body_text
is schema:about of	named entity 'RECEPTOR' named entity 'INTRACELLULAR' named entity 'PRO-' named entity 'RNA POLYMERASE' named entity 'UNIQUE' »more»

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