About: Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans

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About: Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans
Creator	Baskoylu, Saba Cermak, Nathan Clark, Rebekah Flavell, Steven Huang, Yung-Chi »more»
source	PMC
abstract	Animal behaviors are commonly organized into long-lasting states that coordinately impact the generation of diverse motor outputs such as feeding, locomotion, and grooming. However, the neural mechanisms that coordinate these distinct motor programs remain poorly understood. Here, we examine how the distinct motor programs of the nematode C. elegans are coupled together across behavioral states. We describe a new imaging platform that permits automated, simultaneous quantification of each of the main C. elegans motor programs over hours or days. Analysis of these whole-organism behavioral profiles shows that the motor programs coordinately change as animals switch behavioral states. Utilizing genetics, optogenetics, and calcium imaging, we identify a new role for dopamine in coupling locomotion and egg-laying together across states. These results provide new insights into how the diverse motor programs throughout an organism are coordinated and suggest that neuromodulators like dopamine can couple motor circuits together in a state-dependent manner.
has issue date	2020-06-08(xsd:dateTime)
bibo:doi	10.7554/elife.57093
bibo:pmid	32510332
has license	cc-by
sha1sum (hex)	b50f877c0df3facb86d6cae0ef41fa8c8a87af18
schema:url	https://doi.org/10.7554/elife.57093
resource representing a document's title	Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans
has PubMed Central identifier	PMC7347390
has PubMed identifier	32510332
resource representing a document's body	covid:b50f877c0df3facb86d6cae0ef41fa8c8a87af18#body_text
is schema:about of	named entity 'switch' named entity 'optogenetics' named entity 'manner' named entity 'calcium imaging' named entity 'platform' »more»

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