About: COVID‐19 coagulopathy: an in‐depth analysis of the coagulation system

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	COVID‐19 coagulopathy: an in‐depth analysis of the coagulation system
Creator	Demelo-Rodríguez, Pablo Ballesteros, Monica Delgado-Pinos, Valeria Domingo-González, Amalia Luis Díez-Martín, José »more»
source	Medline; PMC
abstract	BACKGROUND: Abnormal coagulation parameters have been reported in COVID‐19 patients. Although the underlying mechanism of COVID‐19 coagulopathy remains unknown, it has been suggested to be a form of disseminated intravascular coagulation (DIC). OBJECTIVES: The aim of our study was to analyze the coagulation parameters of patients with COVID‐19, determine if coagulation factors consumption occurs and identify potential prognostic biomarkers of the disease. PATIENTS/METHODS: Blood samples from hospitalized patients with COVID‐19 pneumonia were collected. We performed basic coagulation tests and quantification of coagulation factors and physiological inhibitor proteins. Laboratory data were compared with clinical data and outcomes. RESULTS: The study involved 206 patients (63.6% male). D‐dimer was particularly elevated (median 450 ng/ml; IQR 222.5‐957.3). Free protein S levels were below the normal range (median 56.6%; IQR: 43.6‐68.9) and factor VIII showed an increasing trend (median 173.4%; IQR: 144.1‐214.9). However, all coagulation factors were within normal limits. We found no correlation between abnormal coagulation parameters and thrombosis, except for higher D‐dimer (HR 1.99; 95% CI 1.3‐3.1; p=0.002). CONCLUSIONS: COVID‐19 is associated with coagulopathy that correlates with poor prognosis. However, we did not demonstrate a consumption of coagulation factors, as seen in DIC.
has issue date	2020-08-04(xsd:dateTime)
bibo:doi	10.1111/ejh.13501
bibo:pmid	32749010
has license	no-cc
sha1sum (hex)	b30353723138053b9b0aa1204aaaa534e5f4c7cf
schema:url	https://doi.org/10.1111/ejh.13501
resource representing a document's title	COVID‐19 coagulopathy: an in‐depth analysis of the coagulation system
has PubMed Central identifier	PMC7436538
has PubMed identifier	32749010
schema:publication	Eur J Haematol
resource representing a document's body	covid:b30353723138053b9b0aa1204aaaa534e5f4c7cf#body_text
is schema:about of	named entity 'coagulopathy' named entity 'COVID-19' named entity 'COVID-19' named entity 'liver function' named entity 'factor VIII' »more»

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