About: Host shifts result in parallel genetic changes when viruses evolve in closely related species

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Host shifts result in parallel genetic changes when viruses evolve in closely related species
Creator	Longdon, Ben Tagliaferri, Lucia Jiggins, Francis Alves, Joel Day, Jonathan »more»
source	BioRxiv; MedRxiv
abstract	Host shifts, where a pathogen invades and establishes in a new host species, are a major source of emerging infectious diseases. They frequently occur between related host species and often rely on the pathogen evolving adaptations that increase their fitness in the novel host species. To investigate genetic changes in novel hosts, we experimentally evolved replicate lineages of an RNA virus (Drosophila C Virus) in 19 different species of Drosophilidae and deep sequenced the viral genomes. We found a strong pattern of parallel evolution, where viral lineages from the same host were genetically more similar to each other than to lineages from other host species. When we compared viruses that had evolved in different host species, we found that parallel genetic changes were more likely to occur if the two host species were closely related. This suggests that when a virus adapts to one host it might also become better adapted to closely related host species. This may explain in part why host shifts tend to occur between related species, and may mean that when a new pathogen appears in a given species, closely related species may become vulnerable to the new disease.
has issue date	2017-11-28(xsd:dateTime)
bibo:doi	10.1101/226175
has license	medrxiv
sha1sum (hex)	b1e7752cbf528db99723a3a67b49b9b5c6e449af
schema:url	https://doi.org/10.1101/226175
resource representing a document's title	Host shifts result in parallel genetic changes when viruses evolve in closely related species
schema:publication	bioRxiv
resource representing a document's body	covid:b1e7752cbf528db99723a3a67b49b9b5c6e449af#body_text
is schema:about of	named entity 'species' named entity 'CHANGES' named entity 'PARALLEL' named entity 'REPLICATE' named entity 'SOURCE' »more»

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