About: Cell proliferation and apoptosis in rat mammary cancer after electrochemical treatment (EChT)

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cell proliferation and apoptosis in rat mammary cancer after electrochemical treatment (EChT)
Creator	Stråhle, K Thörne, A Yongqing, G Von Euler, H
source	Elsevier; Medline; PMC
abstract	Abstract Background: Several authors have recently reported encouraging results from Electrochemical treatment (EChT) in malignant tumours. However, EChT is not established and mechanisms are not completely understood. In vivo studies were conducted to evaluate the toxic changes and effectiveness of EChT on an animal tumour model. Methods: Tumours were induced by injecting cells from the R3230AC rat mammary tumour cell line clone D subcutaneously, in 28 female Fischer 344 rats. EChT was conducted by inserting a platinum electrode into the tumours. The positive and negative control groups were subjected to the same conditions but without current. The rats were kept for 0, 7 or 14 days post-treatment. Three hours prior to euthanasia an i.p. injection of Bromodioxyuridine (BrdU) was given. The rats were euthanized, the lesions extirpated and samples were collected for histopathological, and immunohistochemical examination. Results: Significant changes in cell proliferation rate were seen both in the cathode and anode regions. Apoptosis were induced in the anodic treated area outside the primary necrosis, detected with the TUNEL method. Discussion: The results suggest that secondary cell destruction was caused by necrosis with cathodic EChT and apoptosis or necrosis with anodic EChT.
has issue date	2004-04-30(xsd:dateTime)
bibo:doi	10.1016/j.bioelechem.2003.10.008
bibo:pmid	14990326
has license	els-covid
sha1sum (hex)	b1d13983504af878766bcd98fb793c283e7ab567
schema:url	https://doi.org/10.1016/j.bioelechem.2003.10.008
resource representing a document's title	Cell proliferation and apoptosis in rat mammary cancer after electrochemical treatment (EChT)
has PubMed Central identifier	PMC7129577
has PubMed identifier	14990326
schema:publication	Bioelectrochemistry
resource representing a document's body	covid:b1d13983504af878766bcd98fb793c283e7ab567#body_text
is schema:about of	named entity 'authors' named entity 'induced' named entity 'mammary cancer' named entity 'APOPTOSIS' named entity 'NECROSIS' »more»

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