About: p53- and ROS-mediated AIF pathway involved in TGEV-induced apoptosis

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About: p53- and ROS-mediated AIF pathway involved in TGEV-induced apoptosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	p53- and ROS-mediated AIF pathway involved in TGEV-induced apoptosis
Creator	Ding, Li Li, Na Li, Jiawei Fang, Zhenhua Hong, Meiling »more»
source	Medline; PMC
abstract	We previously demonstrated that transmissible gastroenteritis virus (TGEV) could induce apoptosis through caspase signaling. However, apoptosis was not completely prevented by caspases inhibitors, suggesting that there may be a caspase-independent pathway involved in TGEV-induced cell apoptosis. In this study, we investigated the regulation of apoptosis-inducing factor (AIF) on TGEV-induced apoptotic pathway. Results indicated that AIF translocated from the mitochondria to nucleus during TGEV infection, and the AIF inhibitor, N-phenylmaleimide (NP), significantly attenuated the apoptosis. In addition, the translocation of AIF was inhibited by Veliparib (ABT-888), an inhibitor of poly (ADP-ribose) polymerase (PARP). And the reactive oxygen species (ROS) scavenger, pyrrolidinedithiocarbamic (PDTC), redistributed AIF in the mitochondria and nucleus in TGEV-infected cells. Moreover, the protein levels in nucleus and the mRNA levels of AIF were inhibited in the presence of the p53 inhibitor, piﬁthrin-α (PFT-α) or in TGEV-infected p53−/−cells. Furthermore, TGEV-induced apoptosis was blocked by combination of three or more inhibitors, such as pan caspase inhibitor Z-VAD-FMK, NP, ABT-888, PDTC, PFT-α, to treat PK-15 cells. Taken together, these results suggest that the p53- and ROS-mediated AIF pathway and caspase-dependent pathway were involved in TGEV-induced apoptosis.
has issue date	2018-09-25(xsd:dateTime)
bibo:doi	10.1292/jvms.18-0104
bibo:pmid	30249935
has license	cc-by-nc-nd
sha1sum (hex)	b16cc9a6b9fa37d7b10f17e8b1d2c6dff8783911
schema:url	https://doi.org/10.1292/jvms.18-0104
resource representing a document's title	p53- and ROS-mediated AIF pathway involved in TGEV-induced apoptosis
has PubMed Central identifier	PMC6261820
has PubMed identifier	30249935
schema:publication	J Vet Med Sci
resource representing a document's body	covid:b16cc9a6b9fa37d7b10f17e8b1d2c6dff8783911#body_text
is schema:about of	named entity 'POLYMERASE' named entity 'MITOCHONDRIA' named entity 'INFECTED' named entity 'INVOLVED' named entity 'PDTC' »more»

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