About: Comparative analysis of rodent and small mammal viromes to better understand the wildlife origin of emerging infectious diseases

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About: Comparative analysis of rodent and small mammal viromes to better understand the wildlife origin of emerging infectious diseases Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Comparative analysis of rodent and small mammal viromes to better understand the wildlife origin of emerging infectious diseases
Creator	Liu, Qiyong Yang, Jian Wang, Jianwei Daszak, Peter Du, Jiang »more»
source	Medline; PMC
abstract	BACKGROUND: Rodents represent around 43% of all mammalian species, are widely distributed, and are the natural reservoirs of a diverse group of zoonotic viruses, including hantaviruses, Lassa viruses, and tick-borne encephalitis viruses. Thus, analyzing the viral diversity harbored by rodents could assist efforts to predict and reduce the risk of future emergence of zoonotic viral diseases. RESULTS: We used next-generation sequencing metagenomic analysis to survey for a range of mammalian viral families in rodents and other small animals of the orders Rodentia, Lagomorpha, and Soricomorpha in China. We sampled 3,055 small animals from 20 provinces and then outlined the spectra of mammalian viruses within these individuals and the basic ecological and genetic characteristics of novel rodent and shrew viruses among the viral spectra. Further analysis revealed that host taxonomy plays a primary role and geographical location plays a secondary role in determining viral diversity. Many viruses were reported for the first time with distinct evolutionary lineages, and viruses related to known human or animal pathogens were identified. Phylogram comparison between viruses and hosts indicated that host shifts commonly happened in many different species during viral evolutionary history. CONCLUSIONS: These results expand our understanding of the viromes of rodents and insectivores in China and suggest that there is high diversity of viruses awaiting discovery in these species in Asia. These findings, combined with our previous bat virome data, greatly increase our knowledge of the viral community in wildlife in a densely populated country in an emerging disease hotspot. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40168-018-0554-9) contains supplementary material, which is available to authorized users.
has issue date	2018-10-03(xsd:dateTime)
bibo:doi	10.1186/s40168-018-0554-9
bibo:pmid	30285857
has license	cc-by
sha1sum (hex)	aec276f9c340e5be5f9db9264727cbc8606203e3
schema:url	https://doi.org/10.1186/s40168-018-0554-9
resource representing a document's title	Comparative analysis of rodent and small mammal viromes to better understand the wildlife origin of emerging infectious diseases
has PubMed Central identifier	PMC6171170
has PubMed identifier	30285857
schema:publication	Microbiome
resource representing a document's body	covid:aec276f9c340e5be5f9db9264727cbc8606203e3#body_text
is schema:about of	named entity 'KNOWLEDGE' named entity 'HUMAN' named entity 'EMERGENCE' named entity 'SORICOMORPHA' named entity 'PLAYS' »more»

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