About: Viral genomics in Ebola virus research

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Viral genomics in Ebola virus research
Creator	Palacios, Gustavo Sanchez-Lockhart, Mariano Kuhn, Jens Zeng, Xiankun Di, Nicholas
source	PMC
abstract	Filoviruses such as Ebola virus continue to pose a substantial health risk to humans. Advances in the sequencing and functional characterization of both pathogen and host genomes have provided a wealth of knowledge to clinicians, epidemiologists and public health responders during outbreaks of high-consequence viral disease. Here, we describe how genomics has been historically used to investigate Ebola virus disease outbreaks and how new technologies allow for rapid, large-scale data generation at the point of care. We highlight how genomics extends beyond consensus-level sequencing of the virus to include intra-host viral transcriptomics and the characterization of host responses in acute and persistently infected patients. Similar genomics techniques can also be applied to the characterization of non-human primate animal models and to known natural reservoirs of filoviruses, and metagenomic sequencing can be the key to the discovery of novel filoviruses. Finally, we outline the importance of reverse genetics systems that can swiftly characterize filoviruses as soon as their genome sequences are available.
has issue date	2020-05-04(xsd:dateTime)
bibo:doi	10.1038/s41579-020-0354-7
bibo:pmid	32367066
has license	no-cc
sha1sum (hex)	ae993441f0a859a6512add2e2727ca9ba4ceb66d
schema:url	https://doi.org/10.1038/s41579-020-0354-7
resource representing a document's title	Viral genomics in Ebola virus research
has PubMed Central identifier	PMC7223634
has PubMed identifier	32367066
schema:publication	Nat Rev Microbiol
resource representing a document's body	covid:ae993441f0a859a6512add2e2727ca9ba4ceb66d#body_text
is schema:about of	named entity 'viral' named entity 'infected' named entity 'OUTLINE' named entity 'filoviruses' named entity 'outline' »more»

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