About: An ontology for immune epitopes: application to the design of a broad scope database of immune reactivities

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About: An ontology for immune epitopes: application to the design of a broad scope database of immune reactivities Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	An ontology for immune epitopes: application to the design of a broad scope database of immune reactivities
Creator	Peters, Bjoern Sette, Alessandro Sidney, John Wilson, Stephen Bui, Huynh-Hoa »more»
source	PMC
abstract	BACKGROUND: Epitopes can be defined as the molecular structures bound by specific receptors, which are recognized during immune responses. The Immune Epitope Database and Analysis Resource (IEDB) project will catalog and organize information regarding antibody and T cell epitopes from infectious pathogens, experimental antigens and self-antigens, with a priority on NIAID Category A-C pathogens () and emerging/re-emerging infectious diseases. Both intrinsic structural and phylogenetic features, as well as information relating to the interactions of the epitopes with the host's immune system will be catalogued. DESCRIPTION: To effectively represent and communicate the information related to immune epitopes, a formal ontology was developed. The semantics of the epitope domain and related concepts were captured as a hierarchy of classes, which represent the general and specialized relationships between the various concepts. A complete listing of classes and their properties can be found at . CONCLUSION: The IEDB's ontology is the first ontology specifically designed to capture both intrinsic chemical and biochemical information relating to immune epitopes with information relating to the interaction of these structures with molecules derived from the host immune system. We anticipate that the development of this type of ontology and associated databases will facilitate rigorous description of data related to immune epitopes, and might ultimately lead to completely new methods for describing and modeling immune responses.
has issue date	2005-09-20(xsd:dateTime)
bibo:doi	10.1186/1745-7580-1-2
bibo:pmid	16305755
has license	cc-by
sha1sum (hex)	ae19236936b05793ceac08ed5d58269c25486320
schema:url	https://doi.org/10.1186/1745-7580-1-2
resource representing a document's title	An ontology for immune epitopes: application to the design of a broad scope database of immune reactivities
has PubMed Central identifier	PMC1287064
has PubMed identifier	16305755
schema:publication	Immunome Res
resource representing a document's body	covid:ae19236936b05793ceac08ed5d58269c25486320#body_text
is schema:about of	named entity 'host' named entity 'T cell' named entity 'EPITOPES' named entity 'ONTOLOGY' named entity 'DESIGN' »more»

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