About: Structural maturation of rubella virus in the Golgi complex

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Structural maturation of rubella virus in the Golgi complex
Creator	Risco, Cristina Frey, Teryl Carrascosa, José
source	Elsevier; Medline; PMC
abstract	Abstract Rubella virus is a small enveloped virus that assembles in association with Golgi membranes. Freeze-substitution electron microscopy of rubella virus-infected cells revealed a previously unrecognized virion polymorphism inside the Golgi stacks: homogeneously dense particles without a defined core coexisting with less dense, mature virions that contained assembled cores. The homogeneous particles appear to be a precursor form during the virion morphogenesis process as the forms with mature morphology were the only ones detected inside secretory vesicles and on the exterior of cells. In mature virions potential remnants of C protein membrane insertion were visualized as dense strips connecting the envelope with the internal core. In infected cells Golgi stacks were frequently seen close to cytopathic vacuoles, structures identified as the sites for viral RNA replication, along with the rough endoplasmic reticulum and mitochondria. These associations could facilitate the transfer of viral genomes from the cytopathic vacuoles to the areas of rubella assembly in Golgi membranes.
has issue date	2003-08-01(xsd:dateTime)
bibo:doi	10.1016/s0042-6822(03)00384-2
bibo:pmid	12919732
has license	els-covid
sha1sum (hex)	abc25b132b99ecba2d9f81806d2c211037ba1bba
schema:url	https://doi.org/10.1016/s0042-6822%2803%2900384-2
resource representing a document's title	Structural maturation of rubella virus in the Golgi complex
has PubMed Central identifier	PMC7119121
has PubMed identifier	12919732
schema:publication	Virology
resource representing a document's body	covid:abc25b132b99ecba2d9f81806d2c211037ba1bba#body_text
is schema:about of	named entity 'cells' named entity 'core' named entity 'virion' named entity 'core' named entity 'ENVELOPED VIRUS' »more»

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