About: Metabolomic profiling of mouse mammary tumor derived cell lines reveals targeted therapy options for cancer subtypes

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About: Metabolomic profiling of mouse mammary tumor derived cell lines reveals targeted therapy options for cancer subtypes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Metabolomic profiling of mouse mammary tumor derived cell lines reveals targeted therapy options for cancer subtypes
Creator	Lansing, M Phone,
source	BioRxiv
abstract	Breast cancer is a heterogeneous disease with several subtypes that currently do not have targeted therapy options. Metabolomics has the potential to uncover novel targeted treatment strategies by identifying metabolic pathways required for cancer cells to survive and proliferate. Here, we used tumor-derived cell lines derived from the MMTV-Myc mouse model to investigate metabolic pathways that are differentially utilized between two subtypes of breast cancer. Using mass spectrometry-based metabolomics techniques, we identified differences in glycolysis, the tricarboxylic acid cycle, glutathione metabolism, and nucleotide metabolism between subtypes. We further show the feasibility of targeting these pathways in a subtype-specific manner using metabolism-targeting compounds.
has issue date	2019-10-07(xsd:dateTime)
bibo:doi	10.1101/796573
has license	biorxiv
sha1sum (hex)	aaa376322aacf7fc2195fb1ddf3bc31632bd4d97
schema:url	https://doi.org/10.1101/796573
resource representing a document's title	Metabolomic profiling of mouse mammary tumor derived cell lines reveals targeted therapy options for cancer subtypes
schema:publication	bioRxiv
resource representing a document's body	covid:aaa376322aacf7fc2195fb1ddf3bc31632bd4d97#body_text
is schema:about of	named entity 'targeted' named entity 'cancer' named entity 'survive' named entity 'mouse' named entity 'therapy' »more»

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