About: Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

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About: Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation
Creator	Pingel, Jeanette Thomas, Matthew
source	Elsevier; Medline; PMC
abstract	Abstract The leukocyte-common antigen (L-CA) is a family of large molecular weight glycoproteins uniquely expressed on the surface of all nucleated cells of hematopoletic origin. The glycoprotein consists of a heavily glycosylated exterior domain, a single membrane spanning region, and a large cytoplasmic domain that contains tyrosine phosphatase activity. To investigate the function of this family, we generated T cell clones that lacked L-CA (L-CA−). The expression of the αβ T cell receptor, CD3, CD4, IL-2 receptor (p55), LFA-1, Thy-1, and Pgp-1 (CD44) was normal. The L-CA− T cell clones failed to proliferate in response to antigen or cross-linked CD3; however, they could still proliferate in response to IL-2. An L-CA+ revertant was obtained and the ability to proliferate in response to antigen and cross-linked CD3 was restored. These data indicate that L-CA is required for T cells to enter into cell cycle in response to antigen.
has issue date	1989-09-22(xsd:dateTime)
bibo:doi	10.1016/0092-8674(89)90504-7
bibo:pmid	2550143
has license	els-covid
sha1sum (hex)	a9dee13fda3ced0266934acdee7f68ec5fd64e53
schema:url	https://doi.org/10.1016/0092-8674%2889%2990504-7
resource representing a document's title	Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation
has PubMed Central identifier	PMC7127598
has PubMed identifier	2550143
schema:publication	Cell
resource representing a document's body	covid:a9dee13fda3ced0266934acdee7f68ec5fd64e53#body_text
is schema:about of	named entity 'COMMON' named entity 'HEMATOPOIETIC' named entity 'PGP-1' named entity 'T CELL' named entity 'T CELLS' »more»

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