About: Novel Five‐Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis

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About: Novel Five‐Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Novel Five‐Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis
Creator	Wong, Chi-Huey Lin, Yi-Ling Liang, Pi-Hui Wu, Ying-Ta Lee, Yi-Ling »more»
source	Medline; PMC
abstract	A novel 5‐membered iminocyclitol derivative was found to be a potent and selective inhibitor of the glycoprotein‐processing α‐glucosidase with a K(i) value of 53 nm. This compound was further derivatized to antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN‐2), human SARS coronavirus, and human β‐hexosaminidase (K(i) =2.6 nm), a new target for the development of osteoarthritis therapeutics.
has issue date	2006-01-05(xsd:dateTime)
bibo:doi	10.1002/cbic.200500321
bibo:pmid	16397876
has license	no-cc
sha1sum (hex)	a722ee851a68e24fc199c181c6f4744f20ae9215
schema:url	https://doi.org/10.1002/cbic.200500321
resource representing a document's title	Novel Five‐Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis
has PubMed Central identifier	PMC7161998
has PubMed identifier	16397876
schema:publication	Chembiochem
resource representing a document's body	covid:a722ee851a68e24fc199c181c6f4744f20ae9215#body_text
is schema:about of	named entity 'Inhibitors' named entity 'Osteoarthritis' named entity 'Glycosidase' named entity 'Glycosidase' named entity 'flash column chromatography' »more»

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