About: Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients
Creator	Kopterides, Petros Kotanidou, Anastasia Armaganidis, A Maniatis, Nikolaos Orfanos, Stylianos »more»
source	PMC
abstract	PURPOSE: Endothelial protein C receptor (EPCR) is expressed mainly in endothelial cells and is involved in regulation of the cytoprotective and anticoagulant pathways of protein C. We assessed whether haplotypes in the EPCR gene modify the risk of severe sepsis and/or septic shock (SS/SS) development in critically ill patients. METHODS: Three polymorphisms in the EPCR gene were genotyped in 389 Caucasian critically ill patients, hospitalized in the intensive care units of two major hospitals in Athens, Greece. Multivariate logistic regression analysis controlling for age, acute physiology and chronic health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores, sex, and diagnosis was performed to determine the effect of haplotypes H1 and H3 in the EPCR gene on the development of SS/SS. RESULTS: H2 carriers versus all other genotypes combined had a nonsignificant excess of SS/SS (p = 0.087). SS/SS occurred in 38.8 % of critically ill patients carrying minor alleles belonging to both H1 and H3 haplotypes, in 58.0 % of H1 carriers, 64.3 % of H3 carriers, and 65.2 % of patients carrying all common alleles (H2). Compared with H2 carriers, the odds ratios (OR) for developing SS/SS were 0.34 [95 % confidence interval (CI) 0.16–0.76, p = 0.008] for simultaneous H1 and H3 carriers, 0.65 (95 % CI 0.37–1.13, p = 0.123) for H1 carriers, and 0.82 (95 % CI 0.39–1.70, p = 0.590) for H3 carriers. CONCLUSIONS: Our results indicate that simultaneous carriers of minor alleles belonging to both the H1 and H3 haplotypes may be at reduced risk of developing SS/SS in this cohort of critically ill patients.
has issue date	2013-07-24(xsd:dateTime)
bibo:doi	10.1007/s00134-013-3018-5
bibo:pmid	23881209
has license	no-cc
sha1sum (hex)	a4fbdb7554f4ca881d092572c88d1e2648e496b3
schema:url	https://doi.org/10.1007/s00134-013-3018-5
resource representing a document's title	Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients
has PubMed Central identifier	PMC7095157
has PubMed identifier	23881209
schema:publication	Intensive Care Med
resource representing a document's body	covid:a4fbdb7554f4ca881d092572c88d1e2648e496b3#body_text
is schema:about of	named entity 'confidence interval' named entity 'genotypes' named entity 'APACHE' named entity 'critically ill' named entity 'Multivariate' »more»

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