About: Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients

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About: Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients
Creator	Liu, Xiaoli Zhao, Yan Wang, Wei Wu, Ying Li, Hui »more»
source	PMC
abstract	A novel influenza A (H7N9) virus of avian origin emerged in eastern China in the spring of 2013. This virus causes severe disease in humans, including acute and often lethal respiratory failure. As of January 2014, 275 cases of H7N9-infected patients had been reported, highlighting the urgency of identifying biomarkers for predicting disease severity and fatal outcomes. Here, we show that plasma levels of angiotensin II, a major regulatory peptide of the renin–angiotensin system, are markedly elevated in H7N9 patients and are associated with disease progression. Moreover, the sustained high levels of angiotensin II in these patients are strongly correlated with mortality. The predictive value of angiotensin II is higher than that of C-reactive protein and some clinical parameters such as the PaO(2)/FiO(2) ratio (partial pressure of arterial oxygen to the fraction of inspired oxygen). Our findings indicate that angiotensin II is a biomarker for lethality in flu infections. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/ncomms4595) contains supplementary material, which is available to authorized users.
has issue date	2014-05-06(xsd:dateTime)
bibo:doi	10.1038/ncomms4595
bibo:pmid	24800963
has license	no-cc
sha1sum (hex)	a4dcc00b420ad3efb389adaf2cef001e34a8ca97
schema:url	https://doi.org/10.1038/ncomms4595
resource representing a document's title	Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients
has PubMed Central identifier	PMC7091598
has PubMed identifier	24800963
schema:publication	Nat Commun
resource representing a document's body	covid:a4dcc00b420ad3efb389adaf2cef001e34a8ca97#body_text
is schema:about of	named entity 'PLASMA' named entity 'levels' named entity 'flu' named entity 'renin-angiotensin system' named entity 'patients' »more»

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