About: Social Stress Alters Immune Response and Results in Higher Viral Load During Acute SIV Infection in a Pigtailed Macaque Model of HIV

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About: Social Stress Alters Immune Response and Results in Higher Viral Load During Acute SIV Infection in a Pigtailed Macaque Model of HIV Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Social Stress Alters Immune Response and Results in Higher Viral Load During Acute SIV Infection in a Pigtailed Macaque Model of HIV
Creator	Li, M Graham, D Rubin, L Clements, J Adams, R »more»
source	BioRxiv
abstract	While social distancing is a key response to viral pandemics, social stress has been implicated in adverse health outcomes. A comprehensive understanding of the direct physiologic effects of social stress on viral pathophysiology is needed. To determine the effect of social stress on HIV pathogenesis during acute viral infection without sociobehavioral confounders inherent in human cohorts, we compared commonly measured parameters of HIV progression between singly and socially housed SIV-infected pigtailed macaques (Macaca nemestrina). Singly housed macaques demonstrated lower CD4/CD8 ratios, greater CD4 T cell declines and greater T cell activation compared to socially housed macaques during acute SIV infection. Singly housed macaques furthermore had higher viral loads in the plasma and cerebrospinal fluid throughout acute infection. These data demonstrate that social stress directly impacts the pathogenesis of acute lentiviral infection and imply that social stress has a direct effect on the pathogenesis of HIV and potentially other viral infections. One Sentence Summary Social stress impacts the pathogenesis of acute HIV infection, leading to immune system dysregulation and higher viral load.
has issue date	2020-04-23(xsd:dateTime)
bibo:doi	10.1101/2020.04.21.054130
has license	biorxiv
sha1sum (hex)	a3ce9325060e3d1cbc4deb9c9a81b0992389ff79
schema:url	https://doi.org/10.1101/2020.04.21.054130
resource representing a document's title	Social Stress Alters Immune Response and Results in Higher Viral Load During Acute SIV Infection in a Pigtailed Macaque Model of HIV
schema:publication	bioRxiv
resource representing a document's body	covid:a3ce9325060e3d1cbc4deb9c9a81b0992389ff79#body_text
is schema:about of	named entity 'progression' named entity 'fluid' named entity 'greater' named entity 'declines' named entity 'commonly' »more»

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