About: COVID-19 is an emergent disease of aging

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About: COVID-19 is an emergent disease of aging Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	COVID-19 is an emergent disease of aging
Creator	Gladyshev, Vadim Castro, José Fedichev, Peter Gerashchenko, Maxim Kerepesi, Csaba »more»
source	MedRxiv
abstract	COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 coronavirus that poses one of the greatest challenges to public health in recent years. SARS-CoV-2 is highly contagious and often leads to severe viral pneumonia with respiratory failure and death in the elderly and subjects with pre-existing conditions, but the reason for this age dependence is unclear. Here, we found that the case fatality rate for COVID-19 grows exponentially with age in Italy, Spain, South Korea, and China, with the doubling time approaching that of all-cause human mortality. In addition, men and those with multiple age-related diseases are characterized by increased mortality. Moreover, similar mortality patterns were found for all-cause pneumonia. We further report that the gene expression of ACE2, the SARS-CoV-2 receptor, grows in the lung with age, except for subjects on a ventilator. Together, our findings establish COVID-19 as an emergent disease of aging, and age and age-related diseases as its major risk factors. In turn, this suggests that COVID-19, and deadly respiratory diseases in general, may be targeted, in addition to therapeutic approaches that affect specific pathways, by approaches that target the aging process.
has issue date	2020-04-15(xsd:dateTime)
bibo:doi	10.1101/2020.04.15.20060095
has license	medrxiv
sha1sum (hex)	a364940fb21810bb45ca33457c51653442adfd05
schema:url	https://doi.org/10.1101/2020.04.15.20060095
resource representing a document's title	COVID-19 is an emergent disease of aging
resource representing a document's body	covid:a364940fb21810bb45ca33457c51653442adfd05#body_text
is schema:about of	named entity 'lung' named entity 'patterns' named entity 'COVID-19' named entity 'expression' named entity 'China' »more»

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