About: Insurgence and worldwide diffusion of genomic variants in SARS-CoV-2 genomes

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About: Insurgence and worldwide diffusion of genomic variants in SARS-CoV-2 genomes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Insurgence and worldwide diffusion of genomic variants in SARS-CoV-2 genomes
Creator	Gismondo, Maria Ricagno, Stefano Bandi, Claudio Comandatore, Francesco Gaiarsa, Stefano »more»
source	BioRxiv
abstract	The SARS-CoV-2 pandemic that we are currently experiencing is exerting a massive toll both in human lives and economic impact. One of the challenges we must face is to try to understand if and how different variants of the virus emerge and change their frequency in time. Such information can be extremely valuable as it may indicate shifts in aggressiveness, and it could provide useful information to trace the spread of the virus in the population. In this work we identified and traced over time 7 amino acid variants that are present with high frequency in Italy and Europe, but that were absent or present at very low frequencies during the first stages of the epidemic in China and the initial reports in Europe. The analysis of these variants helps defining 6 phylogenetic clades that are currently spreading throughout the world with changes in frequency that are sometimes very fast and dramatic. In the absence of conclusive data at the time of writing, we discuss whether the spread of the variants may be due to a prominent founder effect or if it indicates an adaptive advantage.
has issue date	2020-05-28(xsd:dateTime)
bibo:doi	10.1101/2020.04.30.071027
has license	biorxiv
sha1sum (hex)	a30e6729cd9edaaa1cab1645ff961e0036c6216a
schema:url	https://doi.org/10.1101/2020.04.30.071027
resource representing a document's title	Insurgence and worldwide diffusion of genomic variants in SARS-CoV-2 genomes
schema:publication	bioRxiv
resource representing a document's body	covid:a30e6729cd9edaaa1cab1645ff961e0036c6216a#body_text
is schema:about of	named entity 'frequencies' named entity 'face' named entity 'Such' named entity 'economic' named entity 'worldwide' »more»

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