About: The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice

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About: The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice
Creator	Yamamoto, Naoki Morikawa, Shigeru Tashiro, Masato Chen, Pei-Jer Hashimoto, Satomi »more»
topic	covid:a1e2a2f6e79ba001e0509a93237be6b79721a9bd#this
source	Elsevier; Medline; PMC
abstract	Abstract We have investigated to develop novel vaccines against SARS CoV using cDNA constructs encoding the structural antigen; spike protein (S), membrane protein (M), envelope protein (E), or nucleocapsid (N) protein, derived from SARS CoV. Mice vaccinated with SARS-N or -M DNA using pcDNA 3.1(+) plasmid vector showed T cell immune responses (CTL induction and proliferation) against N or M protein, respectively. CTL responses were also detected to SARS DNA-transfected type II alveolar epithelial cells (T7 cell clone), which are thought to be initial target cells for SARS virus infection in human. To determine whether these DNA vaccines could induce T cell immune responses in humans as well as in mice, SCID-PBL/hu mice was immunized with these DNA vaccines. As expected, virus-specific CTL responses and T cell proliferation were induced from human T cells. SARS-N and SARS-M DNA vaccines and SCID-PBL/hu mouse model will be important in the development of protective vaccines.
has issue date	2005-03-18(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2005.01.036
bibo:pmid	15755609
has license	els-covid
sha1sum (hex)	a1e2a2f6e79ba001e0509a93237be6b79721a9bd
schema:url	https://doi.org/10.1016/j.vaccine.2005.01.036
resource representing a document's title	The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice
has PubMed Central identifier	PMC7115605
has PubMed identifier	15755609
schema:publication	Vaccine
resource representing a document's body	covid:a1e2a2f6e79ba001e0509a93237be6b79721a9bd#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/a1e2a2f6e79ba001e0509a93237be6b79721a9bd
is schema:about of	named entity 'PBL' named entity 'VACCINES' named entity 'mouse' named entity 'DNA' named entity 'development' »more»

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