About: Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence

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About: Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence
Creator	Gallagher, Tom Heald-Sargent, Taylor
source	Medline; PMC
abstract	Coronavirus-cell entry programs involve virus-cell membrane fusions mediated by viral spike (S) proteins. Coronavirus S proteins acquire membrane fusion competence by receptor interactions, proteolysis, and acidification in endosomes. This review describes our current understanding of the S proteins, their interactions with and their responses to these entry triggers. We focus on receptors and proteases in prompting entry and highlight the type II transmembrane serine proteases (TTSPs) known to activate several virus fusion proteins. These and other proteases are essential cofactors permitting coronavirus infection, conceivably being in proximity to cell-surface receptors and thus poised to split entering spike proteins into the fragments that refold to mediate membrane fusion. The review concludes by noting how understanding of coronavirus entry informs antiviral therapies.
has issue date	2012-04-12(xsd:dateTime)
bibo:doi	10.3390/v4040557
bibo:pmid	22590686
has license	cc-by
sha1sum (hex)	a1add6ab708156c28d4dfa6e0bd825a53c38e418
schema:url	https://doi.org/10.3390/v4040557
resource representing a document's title	Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence
has PubMed Central identifier	PMC3347323
has PubMed identifier	22590686
schema:publication	Viruses
resource representing a document's body	covid:a1add6ab708156c28d4dfa6e0bd825a53c38e418#body_text
is schema:about of	named entity 'interactions' named entity 'activate' named entity 'entering' named entity 'interactions' named entity 'Fusion' »more»

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