About: Genetic and Phenotypic Evidence for the Causal Relationship Between Aging and COVID-19

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Genetic and Phenotypic Evidence for the Causal Relationship Between Aging and COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genetic and Phenotypic Evidence for the Causal Relationship Between Aging and COVID-19
Creator	Gladyshev, Vadim Fedichev, Peter Mariotti, Marco Pyrkov, Timothy Shen, Xia »more»
source	MedRxiv
abstract	Epidemiological studies have revealed that the elderly and those with co-morbidities are most susceptible to COVID-19. To understand the genetic link between aging and the risk of COVID-19, we conducted a multi-instrument Mendelian randomization analysis and found that the genetic variation that leads to a longer lifespan is significantly associated with a lower risk of COVID-19 infection. The odds ratio is 0.32 (95% CI: 0.18 to 0.57; P = 1.3 x 10-4) per additional 10 years of life, and 0.62 (95% CI: 0.51 to 0.77; P = 7.2 x 10-6) per unit higher log odds of surviving to the 90th percentile age. On the other hand, there was no association between COVID-19 susceptibility and healthspan (the lifespan free of the top seven age-related morbidities). To examine the relationship at the phenotypic level, we applied various biological aging clock models and detected an association between the biological age acceleration and future incidence and severity of COVID-19 infection for all subjects as well as for the individuals free of chronic disease. Biological age acceleration was also significantly associated with the risk of death in COVID-19 patients. Our findings suggest a causal relationship between aging and COVID-19, defined by genetic variance, the rate of aging, and the burden of chronic diseases.
has issue date	2020-08-07(xsd:dateTime)
bibo:doi	10.1101/2020.08.06.20169854
has license	medrxiv
sha1sum (hex)	a166581d2ad23a4df466c681ff25fb85c83be87e
schema:url	https://doi.org/10.1101/2020.08.06.20169854
resource representing a document's title	Genetic and Phenotypic Evidence for the Causal Relationship Between Aging and COVID-19
resource representing a document's body	covid:a166581d2ad23a4df466c681ff25fb85c83be87e#body_text
is schema:about of	named entity 'future' named entity 'morbidities' named entity 'Mendelian randomization' named entity 'Evidence' named entity 'models' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software