About: Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase

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About: Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase
Creator	Canard, B Coutard, B Decroly, E Selisko, B Piorkowski, G »more»
topic	covid:a113b31cc4d766f81054056ac31bba60f45c5202#this
source	BioRxiv; Medline; PMC
abstract	The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics. The viral RNA-dependent-RNA-polymerase (RdRp) is a promising target with polymerase inhibitors successfully used for the treatment of several viral diseases. Here we show that Favipiravir exerts an antiviral effect as a nucleotide analogue through a combination of chain termination, slowed RNA synthesis and lethal mutagenesis. The SARS-CoV RdRp complex is at least 10-fold more active than any other viral RdRp known. It possesses both unusually high nucleotide incorporation rates and high-error rates allowing facile insertion of Favipiravir into viral RNA, provoking C-to-U and G-to-A transitions in the already low cytosine content SARS-CoV-2 genome. The coronavirus RdRp complex represents an Achilles heel for SARS-CoV, supporting nucleoside analogues as promising candidates for the treatment of COVID-19.
has issue date	2020-05-15(xsd:dateTime)
bibo:doi	10.1101/2020.05.15.098731
bibo:pmid	32511380
has license	cc-by-nd
sha1sum (hex)	a113b31cc4d766f81054056ac31bba60f45c5202
schema:url	https://doi.org/10.1101/2020.05.15.098731
resource representing a document's title	Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase
has PubMed Central identifier	PMC7263509
has PubMed identifier	32511380
schema:publication	bioRxiv
resource representing a document's body	covid:a113b31cc4d766f81054056ac31bba60f45c5202#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/a113b31cc4d766f81054056ac31bba60f45c5202
is schema:about of	named entity 'chain termination' named entity 'SARS-CoV-2' named entity 'RdRp' named entity 'FOLD' named entity 'GENOME' »more»

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