About: Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases

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About: Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
Creator	Johansson, Magnus Karlsson, Anna Van Rompay, An
source	Elsevier; Medline; PMC
abstract	Abstract Structural analogues of nucleosides, nucleoside analogues (NA), are used in the treatment of cancer and viral infections. Antiviral NAs inhibit replication of the viral genome, whereas anticancer NAs inhibit cellular DNA replication and repair. NAs are inactive prodrugs that are dependent on intracellular phosphorylation to their pharmacologically active triphosphate form. The deoxyribonucleoside kinases (dNK) and ribonucleoside kinases (rNK) catalyze the first phosphorylation step, converting deoxyribonucleosides and ribonucleosides to their corresponding monophosphate form. The dNKs have been studied intensively, whereas the rNKs have not been as thoroughly investigated. This overview is focused on the substrate specificity, tissue distribution, and subcellular location of the mammalian dNKs and rNKs and their role in the activation of NAs.
has issue date	2003-11-30(xsd:dateTime)
bibo:doi	10.1016/j.pharmthera.2003.07.001
bibo:pmid	14609716
has license	els-covid
sha1sum (hex)	a00a13cd289143e5a187a230b800373d45d67264
schema:url	https://doi.org/10.1016/j.pharmthera.2003.07.001
resource representing a document's title	Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
has PubMed Central identifier	PMC7126524
has PubMed identifier	14609716
schema:publication	Pharmacology & Therapeutics
resource representing a document's body	covid:a00a13cd289143e5a187a230b800373d45d67264#body_text
is schema:about of	named entity 'HUMAN' named entity 'investigated' named entity 'anticancer' named entity 'activation' named entity 'human' »more»

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