About: Advanced Molecular Surveillance of Hepatitis C Virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Advanced Molecular Surveillance of Hepatitis C Virus
Creator	Rahal, Paula Escobar-Gutierrez, Alejandro Gonçalves Rossi, Livia
source	PMC
abstract	Hepatitis C virus (HCV) infection is an important public health problem worldwide. HCV exploits complex molecular mechanisms, which result in a high degree of intrahost genetic heterogeneity. This high degree of variability represents a challenge for the accurate establishment of genetic relatedness between cases and complicates the identification of sources of infection. Tracking HCV infections is crucial for the elucidation of routes of transmission in a variety of settings. Therefore, implementation of HCV advanced molecular surveillance (AMS) is essential for disease control. Accounting for virulence is also important for HCV AMS and both viral and host factors contribute to the disease outcome. Therefore, HCV AMS requires the incorporation of host factors as an integral component of the algorithms used to monitor disease occurrence. Importantly, implementation of comprehensive global databases and data mining are also needed for the proper study of the mechanisms responsible for HCV transmission. Here, we review molecular aspects associated with HCV transmission, as well as the most recent technological advances used for virus and host characterization. Additionally, the cornerstone discoveries that have defined the pathway for viral characterization are presented and the importance of implementing advanced HCV molecular surveillance is highlighted.
has issue date	2015-03-13(xsd:dateTime)
bibo:doi	10.3390/v7031153
bibo:pmid	25781918
has license	cc-by
sha1sum (hex)	a007977dad90a07b3beb9f689e3be8b3f7d2a7f6
schema:url	https://doi.org/10.3390/v7031153
resource representing a document's title	Advanced Molecular Surveillance of Hepatitis C Virus
has PubMed Central identifier	PMC4379565
has PubMed identifier	25781918
schema:publication	Viruses
resource representing a document's body	covid:a007977dad90a07b3beb9f689e3be8b3f7d2a7f6#body_text
is schema:about of	named entity 'HCV' named entity 'high' named entity 'HCV' named entity 'molecular' named entity 'genetic heterogeneity' »more»

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