About: Kinetics of viral load and cytokines in severe fever with thrombocytopenia syndrome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Kinetics of viral load and cytokines in severe fever with thrombocytopenia syndrome
Creator	Kim, Sung-Han Choi, Sang-Ho Lee, Sang-Oh Kim, Min-Chul Kwon, Ji-Soo »more»
source	Elsevier; Medline; PMC
abstract	BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in China, Japan, and Korea, which is characterized by high fever, thrombocytopenia, and high mortality. It is hypothesized that a cytokine storm plays an important role in the pathophysiology of SFTS. However, limited data have been published on the detailed kinetics of the viral load and cytokine profiles throughout the course of this disease. OBJECTIVES: We investigated the patterns of changes in cytokines and viral load in SFTS patients. STUDY DESIGN: During the admission period of patients, RNA was extracted from plasma and quantified by reverse transcription polymerase chain reaction. In addition, cytokine bead arrays were performed for the 18 cytokines and chemokines selected for testing. RESULTS: The median time from admission to the negative conversion of SFTS viremia was 17.0 days. When censored patients were found to be negative for viral load at discharge, the median duration of viral shedding was 13.0 days (95% CI, 5.4–20.6). Interferon (IFN)-α, interleukin (IL)-10, and IFN-γ-induced protein (IP)-10 concentrations significantly increased in the early course of disease and then decreased during the hospital stay. However, the concentrations of tumor necrosis factor-α, IL-1β, IL-12p40, IL-13, IL-17A, Regulated on Activation and Normally T-cell Expressed and Secreted (RANTES), and vascular endothelial growth factor (VEGF) increased during the late course of disease. Initial IP-10 levels during hospital days 1–4 were the most significantly correlated with initial viral load (r = 0.88, P < .01). CONCLUSION: SFTS viremia persisted until weeks 2–3 and was highly correlated with initial plasma IP-10 levels. In addition, IFN-α, IL-10, and IP-10 were associated with the initial cytokine storm in SFTS.
has issue date	2018-01-31(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2018.01.017
bibo:pmid	29427908
has license	no-cc
sha1sum (hex)	9d7899c1294d928e2db603c2aeb771340f7151b3
schema:url	https://doi.org/10.1016/j.jcv.2018.01.017
resource representing a document's title	Kinetics of viral load and cytokines in severe fever with thrombocytopenia syndrome
has PubMed Central identifier	PMC7106421
has PubMed identifier	29427908
schema:publication	J Clin Virol
resource representing a document's body	covid:9d7899c1294d928e2db603c2aeb771340f7151b3#body_text
is schema:about of	named entity 'growth factor' named entity 'kinetics' named entity 'T-cell' named entity 'Korea' named entity 'negative' »more»

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