About: In vivo and in vitro models of demyelinating diseases II. Persistence and host-regulated thermosensitivity in cells of neural derivation infected with mouse hepatitis and measles viruses

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About: In vivo and in vitro models of demyelinating diseases II. Persistence and host-regulated thermosensitivity in cells of neural derivation infected with mouse hepatitis and measles viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	In vivo and in vitro models of demyelinating diseases II. Persistence and host-regulated thermosensitivity in cells of neural derivation infected with mouse hepatitis and measles viruses
Creator	Dales, Samuel Anderson, Robert Coulter, Marion Lucas, Alexandra Flintoff', Wayne
source	Elsevier; Medline; PMC
abstract	Abstract Following inoculation of continuous cell lines of neural and other derivations, persistent infections are established with facility by mouse hepatitis and measles viruses. This occurs equally with the prototype MHV3 and its neurotropic variant JHM as well as with the Edmonston vaccine and SSPE Hallé measles variants. In almost every instance that the infection becomes persistent at 32.5°, virus replication is found to be thermosensitive at 39.5°; however, progeny virus derived from such infections at 32.5° is itself thermostable when replicating in the indicator, fully permissive cell lines. The new data, therefore, reveal the existence of a host-conferred interrelationship between persistence and virus restriction at elevated temperature. They indicate that the two agents with neurotropic potential, when they become established as pathogens in the nervous system, could be under close host cell regulation involving as yet unknown mechanisms.
has issue date	1978-07-15(xsd:dateTime)
bibo:doi	10.1016/0042-6822(78)90289-1
bibo:pmid	211715
has license	els-covid
sha1sum (hex)	9d5f75e025f6ba577403aab0eba629ac9433c3a4
schema:url	https://doi.org/10.1016/0042-6822%2878%2990289-1
resource representing a document's title	In vivo and in vitro models of demyelinating diseases II. Persistence and host-regulated thermosensitivity in cells of neural derivation infected with mouse hepatitis and measles viruses
has PubMed Central identifier	PMC7130880
has PubMed identifier	211715
schema:publication	Virology
resource representing a document's body	covid:9d5f75e025f6ba577403aab0eba629ac9433c3a4#body_text
is schema:about of	named entity 'Demyelinating' named entity 'Persistence' named entity 'NEURAL' named entity 'HOST' named entity 'REGULATED' »more»

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