About: Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides

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About: Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides
Creator	Andrei, Graciela Snoeck, Robert Seley-Radtke, Katherine Novikov, Mikhail Babkov, Denis »more»
source	Elsevier; Medline; PMC
abstract	Abstract The need for novel therapeutic options to fight herpesvirus infections still persists. Herein we report the design, synthesis and antiviral evaluation of a new family of non-nucleoside antivirals, derived from 1-[ω-(4-bromophenoxy)alkyl]uracil derivatives – previously reported inhibitors of human cytomegalovirus (HCMV). Introduction of the N-(4-phenoxyphenyl)acetamide side chain at N 3 increased their potency and widened activity spectrum. The most active compounds in the series exhibit submicromolar activity against different viral strains of HCMV and varicella zoster virus (VZV) replication in HEL cell cultures. Inactivity against other DNA and RNA viruses, including herpes simplex virus 1/2, points to a novel mechanism of antiviral action.
has issue date	2015-11-01(xsd:dateTime)
bibo:doi	10.1016/j.bmc.2015.09.033
bibo:pmid	26443550
has license	els-covid
sha1sum (hex)	9d1128280d095834077759a4529827311a6b6708
schema:url	https://doi.org/10.1016/j.bmc.2015.09.033
resource representing a document's title	Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides
has PubMed Central identifier	PMC7126728
has PubMed identifier	26443550
schema:publication	Bioorganic & Medicinal Chemistry
resource representing a document's body	covid:9d1128280d095834077759a4529827311a6b6708#body_text
is schema:about of	named entity 'cell cultures' named entity 'virus' named entity 'uracil' named entity 'acetamides' named entity 'Toward' »more»

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