About: A new factor influencing pathogen detection by molecular assay in children with both mild and severe hand, foot, and mouth disease

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About: A new factor influencing pathogen detection by molecular assay in children with both mild and severe hand, foot, and mouth disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A new factor influencing pathogen detection by molecular assay in children with both mild and severe hand, foot, and mouth disease
Creator	Li, Ning Yao, Yao Dai, Fang-Fang He, Han Jin, Rong-Hua »more»
source	Elsevier; Medline; PMC
abstract	Abstract This study aimed to find novel information concerning pathogen detection and some probable coinfection factors in hand, foot, and mouth disease (HFMD). In this study, 1104 clinically diagnosed HFMD patients were included. Enterovirus 71 (EV71), coxsackievirus A16 (CA16), and 14 different respiratory pathogens were examined from nasopharyngeal swabs using polymerase chain reaction (PCR) or reverse transcriptase PCR (RT-PCR). To evaluate the immune activation in HFMD patients, 8 cytokines and IgM antibodies to EV71 and CA16 from mild and severe patients were detected. Our results indicated that the severity of HFMD may affect the pathogen detection. The lower positive rates of enterovirus and respiratory viruses in severe HFMD cases by RT-PCR were probably related to stronger immune response. Therefore, immunological tests such as ELISA are essential supplements to PCR or RT-PCR in order to increase pathogen diagnosis in HFMD, especially in severe cases.
has issue date	2013-06-30(xsd:dateTime)
bibo:doi	10.1016/j.diagmicrobio.2013.02.011
bibo:pmid	23535205
has license	els-covid
sha1sum (hex)	9b5988df3808813c14e5898f7642f5c32cbc148d
schema:url	https://doi.org/10.1016/j.diagmicrobio.2013.02.011
resource representing a document's title	A new factor influencing pathogen detection by molecular assay in children with both mild and severe hand, foot, and mouth disease
has PubMed Central identifier	PMC7126308
has PubMed identifier	23535205
schema:publication	Diagnostic Microbiology and Infectious Disease
resource representing a document's body	covid:9b5988df3808813c14e5898f7642f5c32cbc148d#body_text
is schema:about of	named entity 'USE' named entity 'RIGHTS' named entity 'FORM' named entity 'THESE' named entity 'PERMISSIONS' »more»

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