About: Erythrocytes Reveal Complement Activation in Patients with COVID-19

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Erythrocytes Reveal Complement Activation in Patients with COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Erythrocytes Reveal Complement Activation in Patients with COVID-19
Creator	Betts, Michael Lam, Meyer, Nuala Cines, Douglas Lambris, John »more»
source	MedRxiv; Medline
abstract	COVID-19, the disease caused by the SARS-CoV-2 virus, can progress to multi-organ failure characterized by respiratory insufficiency, arrhythmias, thromboembolic complications and shock. The mortality of patients hospitalized with COVID-19 is unacceptably high and new strategies are urgently needed to rapidly identify and treat patients at risk for organ failure. Clinical epidemiologic studies demonstrate that vulnerability to organ failure is greatest after viral clearance from the upper airway, which suggests that dysregulation of the host immune response is a critical mediator of clinical deterioration and death. Autopsy and pre-clinical evidence implicate aberrant complement activation in endothelial injury and organ failure. A potential therapeutic strategy warranting investigation is to inhibit complement, with case reports of successful treatment of COVID-19 with inhibitors of complement. However, this approach requires careful balance between the host protective and potential injurious effects of complement activation, and biomarkers to identify the optimal timing and candidates for therapy are lacking. Here we report the presence of complement activation products on circulating erythrocytes from hospitalized COVID-19 patients using flow cytometry. These findings suggest that novel erythrocyte-based diagnostics provide a method to identify patients with dysregulated complement activation.
has issue date	2020-05-22(xsd:dateTime)
bibo:doi	10.1101/2020.05.20.20104398
bibo:pmid	32511554
has license	medrxiv
sha1sum (hex)	99a9b1b18f38bd74b49d7f1773381a64f6e77449
schema:url	https://doi.org/10.1101/2020.05.20.20104398
resource representing a document's title	Erythrocytes Reveal Complement Activation in Patients with COVID-19
has PubMed identifier	32511554
schema:publication	medRxiv : the preprint server for health sciences
resource representing a document's body	covid:99a9b1b18f38bd74b49d7f1773381a64f6e77449#body_text
is schema:about of	named entity 'patients' named entity 'needed' named entity 'SARS-CoV-2' covid:arg/99a9b1b18f38bd74b49d7f1773381a64f6e77449 named entity 'caused' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software