About: Angiotensin-Converting Enzyme 2: The First Decade

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Angiotensin-Converting Enzyme 2: The First Decade
Creator	Clarke, Nicola Turner, Anthony
source	Medline; PMC
abstract	The renin-angiotensin system (RAS) is a critical regulator of hypertension, primarily through the actions of the vasoactive peptide Ang II, which is generated by the action of angiotensin-converting enzyme (ACE) mediating an increase in blood pressure. The discovery of ACE2, which primarily metabolises Ang II into the vasodilatory Ang-(1-7), has added a new dimension to the traditional RAS. As a result there has been huge interest in ACE2 over the past decade as a potential therapeutic for lowering blood pressure, especially elevation resulting from excess Ang II. Studies focusing on ACE2 have helped to reveal other actions of Ang-(1-7), outside vasodilation, such as antifibrotic and antiproliferative effects. Moreover, investigations focusing on ACE2 have revealed a variety of roles not just catalytic but also as a viral receptor and amino acid transporter. This paper focuses on what is known about ACE2 and its biological roles, paying particular attention to the regulation of ACE2 expression. In light of the entrance of human recombinant ACE2 into clinical trials, we discuss the potential use of ACE2 as a therapeutic and highlight some pertinent questions that still remain unanswered about ACE2.
has issue date	2011-11-10(xsd:dateTime)
bibo:doi	10.1155/2012/307315
bibo:pmid	22121476
has license	cc-by
sha1sum (hex)	98d83658e5a7c2174de3524a9a3b7c057a34b085
schema:url	https://doi.org/10.1155/2012/307315
resource representing a document's title	Angiotensin-Converting Enzyme 2: The First Decade
has PubMed Central identifier	PMC3216391
has PubMed identifier	22121476
schema:publication	Int J Hypertens
resource representing a document's body	covid:98d83658e5a7c2174de3524a9a3b7c057a34b085#body_text
is schema:about of	named entity 'regulation' named entity 'ANG' named entity 'reveal' named entity 'remain' named entity 'ACE2' »more»

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