About: Association between Alzheimer's disease and COVID-19: A bidirectional Mendelian randomization

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About: Association between Alzheimer's disease and COVID-19: A bidirectional Mendelian randomization Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Association between Alzheimer's disease and COVID-19: A bidirectional Mendelian randomization
Creator	Wang, Wei Zhang, Jie Liu, Di Zhang, Xiaoyu Xing, Weijia »more»
source	MedRxiv
abstract	Background In observational studies, Alzheimer's disease (AD) has been associated with an increased risk of Coronavirus disease 2019 (COVID-19), and the prognosis of COVID-19 can affect nervous systems. However, the causality between these conditions remains to be determined. Methods This study sought to investigate the bidirectional causal relations of AD with COVID-19 using two-sample Mendelian randomization (MR) analysis. Results We found that genetically predicted AD was significantly associated with higher risk of severe COVID-19 (odds ratio [OR], 3.329; 95% confidence interval [CI], 1.139-9.725; P=0.028). It's interesting that genetically predicted severe COVID-19 was also significantly associated with higher risk of AD (OR, 1.004; 95% CI, 1.001-1.007; P=0.018). In addition, the two strong genetic variants associated with severe COVID-19 was associated with higher AD risk (OR, 1.018; 95% CI, 1.003-1.034; P=0.018). There is no evidence to support that genetically predicted AD was significantly associated with COVID-19 susceptibility, and vice versa. No obvious pleiotropy bias and heterogeneity were observed. Conclusion Overall, AD may causally affect severe COVID-19, and vice versa, performing bidirectional regulation through independent biological pathways.
has issue date	2020-07-30(xsd:dateTime)
bibo:doi	10.1101/2020.07.27.20163212
has license	medrxiv
sha1sum (hex)	95e80dfdb41c1eb09b0a473c4d2b29a3103b74c6
schema:url	https://doi.org/10.1101/2020.07.27.20163212
resource representing a document's title	Association between Alzheimer's disease and COVID-19: A bidirectional Mendelian randomization
resource representing a document's body	covid:95e80dfdb41c1eb09b0a473c4d2b29a3103b74c6#body_text
is schema:about of	named entity 'causality' named entity 'Alzheimer's disease' named entity 'observational studies' named entity 'prognosis' named entity 'COVID-19' »more»

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