About: The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis
Creator	Fotuhi, M Meysami, S Mian, A Raji, C
source	BioRxiv
abstract	Most patients with COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), display neurological symptoms, and respiratory failure in certain cases could be of extra-pulmonary origin. Hypothalamic neural circuits play key roles in sex differences, diabetes, hypertension, obesity and aging, all risk factors for severe COVID-19, besides being connected to olfactory/gustative and brainstem cardiorespiratory centers. Here, human brain gene-expression analyses and immunohistochemistry reveal that the hypothalamus and associated regions express angiotensin-converting enzyme 2 and transmembrane proteinase, serine 2, which mediate SARS-CoV-2 cellular entry, in correlation with genes or pathways involved in physiological functions or viral pathogenesis. A post-mortem patient brain shows viral invasion and replication in both the olfactory bulb and the hypothalamus, while animal studies indicate that sex hormones and metabolic diseases influence this susceptibility.
has issue date	2020-06-19(xsd:dateTime)
bibo:doi	10.1101/2020.06.08.139329
has license	biorxiv
sha1sum (hex)	94fb7c08abea5aa0e1c582a2c02508931a2d4be4
schema:url	https://doi.org/10.1101/2020.06.08.139329
resource representing a document's title	The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis
schema:publication	bioRxiv
resource representing a document's body	covid:94fb7c08abea5aa0e1c582a2c02508931a2d4be4#body_text
is schema:about of	named entity 'involved' named entity 'risk factors' named entity 'neurological' named entity 'physiological' named entity 'analyses' »more»

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