About: COVID-19 induces a hyperactive phenotype in circulating platelets

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	COVID-19 induces a hyperactive phenotype in circulating platelets
Creator	Altaie, Haidar Comer, Shane Cullen, Steven Cullivan, Sarah Curran, John »more»
source	MedRxiv
abstract	Background Coronavirus disease 2019 (COVID-19), caused by novel coronavirus SARS-CoV-2, has to date affected over 13.3 million globally. Although high rates of venous thromboembolism and evidence of COVID-19-induced endothelial dysfunction have been reported, the precise aetiology of the increased thrombotic risk associated with COVID-19 infection remains to be fully elucidated. Objectives Here, we assessed clinical platelet parameters and circulating platelet activity in patients with severe and non-severe COVID-19. Methods An assessment of clinical blood parameters in patients with severe COVID-19 disease (requiring intensive care), patients with non-severe disease (not requiring intensive care), general medical in-patients without COVID-19 and healthy donors was undertaken. Platelet function and activity were also assessed by secretion and specific marker analysis. Results We show that routine clinical blood parameters including increased MPV and decreased platelet:neutrophil ratio are associated with disease severity in COVID-19 upon hospitalisation and intensive care unit admission. Strikingly, agonist-induced ADP release was dramatically higher in COVID-19 patients compared with non-COVID-19 hospitalized patients and circulating levels of PF4, sP-selectin and TPO were also significantly elevated in COVID-19. Conclusion Distinct differences exist in routine full blood count and other clinical laboratory parameters between patients with severe and non-severe COVID-19. Moreover, we have determined that COVID-19 patients possess hyperactive circulating platelets. These data suggest that abnormal platelet reactivity may contribute to hypercoagulability in COVID-19. Further investigation of platelet function in COVID-19 may provide additional insights into the aetiology of thrombotic risk in this disease and may contribute to the optimisation of thrombosis prevention and treatment strategies.
has issue date	2020-07-26(xsd:dateTime)
bibo:doi	10.1101/2020.07.24.20156240
has license	medrxiv
sha1sum (hex)	94f0e3ee187c6c17a28f01ce39f5dbc9ad2faa73
schema:url	https://doi.org/10.1101/2020.07.24.20156240
resource representing a document's title	COVID-19 induces a hyperactive phenotype in circulating platelets
resource representing a document's body	covid:94f0e3ee187c6c17a28f01ce39f5dbc9ad2faa73#body_text
is schema:about of	named entity 'hyperactive' named entity 'phenotype' named entity 'COVID-19 pandemic' named entity 'platelet' named entity 'dense granule' »more»

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